440370-28-5Relevant academic research and scientific papers
Pseudoephedrine as a chiral auxiliary for asymmetric Michael reactions: synthesis of 3-aryl-delta-lactones.
Smitrovich, Jacqueline H,Boice, Genevieve N,Qu, Chuanxing,DiMichele, Lisa,Nelson, Todd D,Huffman, Mark A,Murry, Jerry,McNamara, James,Reider, Paul J
, p. 1963 - 1966 (2002)
[reaction: see text] The asymmetric Michael reaction of pseudoephedrine amides is reported. The 1,5-dicarbonyl products are converted to 3-aryl-delta-lactones in a two-step reduction/lactonization sequence. This method provides access to enantiomerically enriched trans-3,4-disubstituted delta-lactones.
