440370-33-2Relevant academic research and scientific papers
Discovery and Characterization of 2-Aminooxazolines as Highly Potent, Selective, and Orally Active TAAR1 Agonists
Galley, Guido,Beurier, Angélica,Décoret, Guillaume,Goergler, Annick,Hutter, Roman,Mohr, Susanne,P?hler, Axel,Schmid, Philipp,Türck, Dietrich,Unger, Robert,Zbinden, Katrin Groebke,Hoener, Marius C.,Norcross, Roger D.
supporting information, p. 192 - 197 (2016/03/01)
2-Aminooxazolines were discovered as a novel structural class of TAAR1 ligands. Starting from a known adrenergic compound 1, structural modifications were made to obtain highly potent and selective TAAR1 ligands such as 12 (RO5166017), 18 (RO5256390), 36 (RO5203648), and 48 (RO5263397). These compounds exhibit drug-like physicochemical properties, have good oral bioavailability, and display in vivo activity in a variety of animal models relevant for psychiatric diseases and addiction.
Michael Reactions of Pseudoephedrine Amide Enolates: Effect of LiCl on Syn/Anti Selectivity
Smitrovich, Jacqueline H.,DiMichele, Lisa,Qu, Chuanxing,Boice, Genevieve N.,Nelson, Todd D.,Huffman, Mark A.,Murry, Jerry
, p. 1903 - 1908 (2007/10/03)
The stereochemical outcome of the asymmetric Michael reaction of pseudoephedrine amide enolates changes dramatically in the presence of LiCl. Reaction of the enolate in the absence of LiCl results in formation of the anti Michael adduct with high selectiv
