4404-98-2

Usage

Uses

Used in Chemical Synthesis:
4-amino-4-methylpentan-2-ol is used as a reagent in chemical reactions for the synthesis of various compounds. Its dual functional groups allow it to participate in a wide range of reactions, making it a valuable building block in the production of complex molecules.
Used in Polymer Production:
In the polymer industry, 4-amino-4-methylpentan-2-ol is used as a monomer or a comonomer in the production of polymers. Its structural characteristics enable it to contribute to the formation of polymer chains with specific properties, such as flexibility, strength, or reactivity, depending on the desired application.
Used in Pharmaceutical Development:
4-amino-4-methylpentan-2-ol is used as a starting material or an intermediate in the synthesis of pharmaceutical compounds. Its unique structure can be exploited to design new drugs with potential therapeutic applications, taking advantage of its reactivity and the ability to form stable bonds with other molecules.
Used in Material Science:
In material science, 4-amino-4-methylpentan-2-ol is used as a component in the development of new materials with specific properties. Its ability to form hydrogen bonds and interact with other molecules can contribute to the creation of materials with tailored characteristics, such as improved mechanical strength, thermal stability, or chemical resistance.

Upstream product

• 556-72-9 2,2,4,4,6-pentamethyl-2,3,4,5,tetrahydropyrimidine 
• 141-79-7 4-methyl-pent-3-en-2-one 
• 91875-52-4 N-(3-hydroxy-1,1-dimethyl-butyl)-acetamide 
• 625-04-7 4-amino-4-methylpentan-2-one 
• 35614-83-6 5-Hydroxy-3,3,5-trimethylisoxazolidine 
• 135865-44-0 2-(2-phenethyl)-4,4,6-trimethyltetrahydro-1,3-oxazine 
• 41608-07-5 azido-4 methyl-4 pentanone-2 
• 36873-27-5 2-ethyl-4,4,6-trimethyltetrahydro-1,3-oxazine 
• 112980-86-6 Me₂(CH₂)2NHOB-C₄H₉-iso 
• 134-81-6 benzil 
• 31771-33-2 2-phenyl-4,4,6-trimethyltetrahydro-(2H)-1,3-oxazine 
• 7732-18-5 water 
• 64-17-5 ethanol 
• 26939-18-4 2,4,4,6-tetramethyl-5,6-dihydro-4H-1,3-oxazine 

Downstream Products

• 5422-40-2 N-(3-hydroxy-1,1-dimethyl-butyl)-lactamide 
• 27830-77-9 4,4,6-trimethyl-tetrahydro-[1,3]oxazin-2-one 
• 31771-33-2 2-phenyl-4,4,6-trimethyltetrahydro-(2H)-1,3-oxazine 
• 18774-36-2 N-benzyl-diacetonalkamine 
• 37723-86-7 N-(3-hydroxy-1,1-dimethyl-butyl)-N'-phenyl-thiourea 
• 135865-44-0 2-(2-phenethyl)-4,4,6-trimethyltetrahydro-1,3-oxazine 
• 100098-71-3 (E)-N-(3-hydroxy-1,1-dimethylbutyl) cinnamamide 
• 620-40-6 tribenzylamine 
• 100098-78-0 2-[(E)-2-(3-Bromo-phenyl)-vinyl]-4,4,6-trimethyl-5,6-dihydro-4H-[1,3]oxazine; hydrochloride 
• 100098-79-1 2-[(E)-2-(3-Chloro-phenyl)-vinyl]-4,4,6-trimethyl-5,6-dihydro-4H-[1,3]oxazine; hydrochloride 
• 100098-83-7 4,4,6-Trimethyl-2-((E)-2-naphthalen-1-yl-vinyl)-5,6-dihydro-4H-[1,3]oxazine; hydrochloride 
• 53004-48-1 phenyl-(4,4,6-trimethyl-5,6-dihydro-4H-[1,3]thiazin-2-yl)-amine 
• 73160-80-2 4,4,6-trimethyl-2-(2-phenyl-hexyl)-5,6-dihydro-4H-[1,3]oxazine 
• 26939-22-0 2-benzyl-4,4,6-trimethyl-5,6-dihydro-4H-[1,3]oxazine 

Relevant academic research and scientific papers

General synthetic approach towards annelated 3a,6-epoxyisoindoles by tandem acylation/IMDAF reaction of furylazaheterocycles. Scope and limitations

An efficient and versatile one-pot synthesis of 3,6a-epoxyisoindoles annelated with oxazine, oxazole, thiazine, thiazole, pyrimidine fragments and with their benzoannelated analogues is presented. The method is based on tandem N-acylation/intramolecular cycloaddition (the intramolecular Diels-Alder reaction of furan, IMDAF) reaction between α,β-unsaturated acid anhydrides and α-furyl substituted azaheterocycles. The latter can be easily prepared by condensation of diverse furfurals and 1,2- or 1,3-N,X-binucleophiles (aminoalcohols, aminothiols, diamines). The observed IMDAF reaction is stereoselective: exo-adducts are formed exclusively with large prevalence of one of the diastereoisomers. In most cases, the condensation/N-acylation/IMDAF reaction sequence may be carried out via a one-pot domino protocol. The scope and limitations of the proposed approach are thoroughly investigated. The obtained Diels-Alder adducts are attractive and useful substrates for further transformations. Fused isoindoles can be prepared from them in one-step by aromatization of the 7-oxabicyclo[2.2.1]heptene ring. Other transformations, including halogenation, ring cleavage, and Wagner-Meerwein skeletal rearrangement, are also demonstrated. The spatial structures of the obtained compounds have been established by X-ray diffraction analyses.

Reaction of 2-isobutoxy-4,4,6-trimethyl-1,3,2-dioxaborinane with dinitriles

2-Isobutoxy-4,4,6-trimethyl-1,3,2-dioxaborinane reacts with bis(2-cyanoethyl) ether and bis[2-(2-cyanoethoxy)ethyl] ether to afford the corresponding bis(5,6-dihydro-4,4,6-trimethyl-1,3-4H-oxazin-2-yl) derivatives which are readily hydrolyzed in aqueous alkali, yielding 4-amino-4-methyl-2-pentanol.

Reduction of azides to amines mediated by tin bis(1,2-benzenedithiolate)

(matrix presented) A procedure for the conversion of azides to amines, which uses NaBH4 and catalytic amounts of tin(IV) 1,2-benzenedithiolate, is disclosed. Primary, secondary, tertiary, aromatic, and heteroaromatic azides are reduced in excellent yields under very mild conditions.

Phosphoramidate analogs of 2'-deoxyuridine

The present invention provides a series of cytotoxic phosphoramidate analogs of 5-fluoro-2'-deoxyuridine of the general formula (I): STR1 wherein R1 is H, F or (C1 -C4)alkyl; R2 is CH2 CH2 X wherein X is Cl, Br, I or p-toluenesulfonyl; R3 is (C1 -C4)alkyl or CH2 CH2 X wherein X is Cl, Br, I or p-toluenesulfonyl; or wherein R2 and R3, taken together with the N atom, can be a 5- or 6-membered heterocyclic ring which is aliphatic or aliphatic interrupted by a ring oxygen or a second ring nitrogen; R4 is H, one equivalent of a pharmaceutically-acceptable cation or (4,4,6-trimethyltetrahydro-1,3-oxazin-2-yl)ethyl, and the pharmaceutically-acceptable salts thereof.

Reduction of azides to amines with borohydride exchange resin - Nickel acetate

Borohydride exchange resin (BER) - nickel acetate system in methanol readily reduces both aliphatic and aromatic azides to the corresponding amines in excellent yields.

Synthesis, Activation, and Cytotoxicity of Aldophosphamide Analogues

A series of perhydrooxazine analogues of aldophosphamide has been prepared, and their 31P NMR kinetics and in vitro cytotoxicity have been evaluated.These compounds were developed on the basis of the idea that ring opening and tautomerization to an enamine intermediate might provide a mechanistic alternative to the β-elimination reaction for release of phosphoramide mustard.The 4,4,6-trimethyltetrahydro-1,3-oxazine moiety was selected on the basis of its rapid rate of iminium ion generation and relatively slow rate of hydrolysis.These analogues underwent phosphorodiamidate release by three distinct mechanisms: hydrolysis to aldophosphamide and subsequent β-elimination; cyclization to produce the 4-hydroxycyclophosphamides, which release phosphorodiamidate by ring opening and elimination; and tautomerization to the enamine with rapid expulsion of phosphorodiamidate.Kinetic studies demonstrated that hydrolysis to the aldehyde contributed minimally to the overall activation process and that the enamine pathway represented the major route of activation.For those analogues that could undergo cyclization this pathway competed effectively with enamine release, and these analogues were essentially equivalent to their 4-hydroxycyclophosphamide counterparts in cytotoxicity.A series of tetra-N-substituted phosphorodiamidates that cannot undergo cyclization was prepared to explore the effects of cyclization on the cytotoxicity of these analogues.The tetrakis(chloroethyl)phosphorodiamidates were highly potent in vitro against both cyclophosphamide-sensitive and -resistant L1210 and P388 cell lines, and one of these analogues had significant antitumor activity against L1210 leukemia in vivo.These results demonstrate that the enamine mechanism provides a viable pathway for delivery of phosphorodiamidates and that this approach can be used to deliver phosphorodiamidates that are non-cross-resistant in cyclophosphamide-resistant cell lines.

Aldophosphamide derivatives useful as antitumor agents

A compound of the formula STR1 wherein R1 and R2 may be the same of different and are each independently hydrogen or lower alkyl which may be unsubstituted or monosubstituted with halogen, lower alkoxy or hydroxy with the proviso that the substituent is not the α-carbon or R1 and R2 taken together with the carbon to which they are attached form a morpholino ring; each R3 is independently hydrogen, lower alkyl, carboxy or carbalkoxy; n is an integer from 0, 1, 2 or 3 and R is hydrogen, lower alkyl, cycloalkyl, arylalkyl aryl or a nitrogen, sulfur or oxygen containing heterocyclic or a heterocyclic lower alkyl and pharmacuetically acceptable salts thereof.