4404-98-2

Basic information

• Product Name: 4-amino-4-methylpentan-2-ol
• Synonyms: 4-Amino-4-methylpentan-2-ol
• CAS NO: 4404-98-2
• Molecular Formula: C₆H₁₅NO
• Molecular Weight: 117.1894
• EINECS: 224-550-8
• Mol File: 4404-98-2.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 174.5°C at 760 mmHg
• Flash Point: 69.7°C
• Density: 0.907g/cm³
• Vapor Pressure: 0.373mmHg at 25°C
• Refractive Index: 1.451
• CAS DataBase Reference: 4-amino-4-methylpentan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-amino-4-methylpentan-2-ol(4404-98-2)
• EPA Substance Registry System: 4-amino-4-methylpentan-2-ol(4404-98-2)

Safety Data

• Hazardous Substances Data: 4404-98-2(Hazardous Substances Data)

Usage

General Description

4-amino-4-methylpentan-2-ol is a chemical compound with a molecular formula of C6H15NO. Characterized by the presence of both an amino and a hydroxyl functional group, it falls into the category of organic compounds known as amino alcohols. As an amino alcohol, it exhibits properties of both amines and alcohols. Given its structural characteristics, the compound has potential applications in various industrial and scientific contexts, such as in the production of polymers or as a reagent in chemical reactions. However, its specific properties, such as boiling point, melting point, solubility, and potential toxicity, would need to be considered in relation to its intended use. As with any chemical substance, appropriate precautions should be taken when handling 4-amino-4-methylpentan-2-ol.

Upstream product

• 556-72-9 2,2,4,4,6-pentamethyl-2,3,4,5,tetrahydropyrimidine 
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• 91875-52-4 N-(3-hydroxy-1,1-dimethyl-butyl)-acetamide 
• 625-04-7 4-amino-4-methylpentan-2-one 
• 64-17-5 ethanol 
• 40652-47-9 2-acetylamino-2-methyl-4-pentanone 
• 26939-18-4 2,4,4,6-tetramethyl-5,6-dihydro-4H-1,3-oxazine 
• 31771-33-2 2-phenyl-4,4,6-trimethyltetrahydro-(2H)-1,3-oxazine 
• 7732-18-5 water 
• 112980-86-6 Me₂(CH₂)2NHOB-C₄H₉-iso 
• 134-81-6 benzil 
• 36873-27-5 2-ethyl-4,4,6-trimethyltetrahydro-1,3-oxazine 
• 41608-07-5 azido-4 methyl-4 pentanone-2 
• 135865-44-0 2-(2-phenethyl)-4,4,6-trimethyltetrahydro-1,3-oxazine 

Downstream Products

• 5422-40-2 N-(3-hydroxy-1,1-dimethyl-butyl)-lactamide 
• 31771-33-2 2-phenyl-4,4,6-trimethyltetrahydro-(2H)-1,3-oxazine 
• 18774-36-2 N-benzyl-diacetonalkamine 
• 135865-44-0 2-(2-phenethyl)-4,4,6-trimethyltetrahydro-1,3-oxazine 
• 620-40-6 tribenzylamine 
• 100098-78-0 2-[(E)-2-(3-Bromo-phenyl)-vinyl]-4,4,6-trimethyl-5,6-dihydro-4H-[1,3]oxazine; hydrochloride 
• 100098-79-1 2-[(E)-2-(3-Chloro-phenyl)-vinyl]-4,4,6-trimethyl-5,6-dihydro-4H-[1,3]oxazine; hydrochloride 
• 100098-83-7 4,4,6-Trimethyl-2-((E)-2-naphthalen-1-yl-vinyl)-5,6-dihydro-4H-[1,3]oxazine; hydrochloride 
• 53004-48-1 phenyl-(4,4,6-trimethyl-5,6-dihydro-4H-[1,3]thiazin-2-yl)-amine 
• 27830-77-9 4,4,6-trimethyl-tetrahydro-[1,3]oxazin-2-one 
• 150756-43-7 3'-O-(tert-butyldimethylsilyl)-5-fluoro-2'-deoxy-5'-uridyl-2-(4,4,6-trimethyltetrahydro-1,3-oxazin-2-yl)ethyl N-methyl-N-(2-tosylethyl)phosphoramidate 
• 100098-71-3 (E)-N-(3-hydroxy-1,1-dimethylbutyl) cinnamamide 
• 73160-80-2 4,4,6-trimethyl-2-(2-phenyl-hexyl)-5,6-dihydro-4H-[1,3]oxazine 
• 26939-22-0 2-benzyl-4,4,6-trimethyl-5,6-dihydro-4H-[1,3]oxazine 

Relevant articles and documents

General synthetic approach towards annelated 3a,6-epoxyisoindoles by tandem acylation/IMDAF reaction of furylazaheterocycles. Scope and limitations

An efficient and versatile one-pot synthesis of 3,6a-epoxyisoindoles annelated with oxazine, oxazole, thiazine, thiazole, pyrimidine fragments and with their benzoannelated analogues is presented. The method is based on tandem N-acylation/intramolecular cycloaddition (the intramolecular Diels-Alder reaction of furan, IMDAF) reaction between α,β-unsaturated acid anhydrides and α-furyl substituted azaheterocycles. The latter can be easily prepared by condensation of diverse furfurals and 1,2- or 1,3-N,X-binucleophiles (aminoalcohols, aminothiols, diamines). The observed IMDAF reaction is stereoselective: exo-adducts are formed exclusively with large prevalence of one of the diastereoisomers. In most cases, the condensation/N-acylation/IMDAF reaction sequence may be carried out via a one-pot domino protocol. The scope and limitations of the proposed approach are thoroughly investigated. The obtained Diels-Alder adducts are attractive and useful substrates for further transformations. Fused isoindoles can be prepared from them in one-step by aromatization of the 7-oxabicyclo[2.2.1]heptene ring. Other transformations, including halogenation, ring cleavage, and Wagner-Meerwein skeletal rearrangement, are also demonstrated. The spatial structures of the obtained compounds have been established by X-ray diffraction analyses.

Reduction of azides to amines mediated by tin bis(1,2-benzenedithiolate)

(matrix presented) A procedure for the conversion of azides to amines, which uses NaBH4 and catalytic amounts of tin(IV) 1,2-benzenedithiolate, is disclosed. Primary, secondary, tertiary, aromatic, and heteroaromatic azides are reduced in excellent yields under very mild conditions.

Reduction of azides to amines with borohydride exchange resin - Nickel acetate

Borohydride exchange resin (BER) - nickel acetate system in methanol readily reduces both aliphatic and aromatic azides to the corresponding amines in excellent yields.