440635-71-2

Upstream product

• 30192-14-4 7-hydroxy-8-nitro-4-oxo-4H-chromene-2-carboxylic acid ethyl ester 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 440635-72-3 ethyl-7-benzylamino-8-nitro-4-oxo-4H-chromene-2-carboxylate 
• 440635-76-7 Toluene-4-sulfonic acid 2-trifluoromethyl-3,6,7,8-tetrahydro-9-oxa-1,3-diaza-cyclopenta[a]naphthalen-8-ylmethyl ester 
• 440635-79-0 toluene-4-sulfonic acid-2-oxo-1,2,3,6,7,8-hexahydro-9-oxa-1,3-diaza-cyclopenta[a]naphthalen-8-ylmethyl ester 

Relevant academic research and scientific papers

New generation dopaminergic agents. Part 8: Heterocyclic bioisosteres that exploit the 7-OH-2-(aminomethyl)chroman D2 template

Based on the 7-OH-2-(aminomethyl)chroman dopamine D2 template (2) is described the preparation and resolution of two bioisosteric analogues. The benzimidazol-2-one derivative (6) had similar affinity to the known indolone derivative (4).

2-(aminomethyl)-tetrahydro-9-oxa-1,3-diaza-cyclopenta[a]-naphthalenyl derivatives with antipsychotic activity

Compounds of the Formula (I): are useful in the treatment of disorders associated with brain dopamine dysregulation.

2-(aminomethyl)-tetrahydro-9-oxa-1,3-diaza-cyclopenta[a]-naphthalenyl derivatives with antipsychotic activity

Compounds of the Formula (I): are useful in the treatment of disorders associated with dopamine dysregulation.