440677-21-4

Upstream product

• 56-86-0 L-glutamic acid 
• 13154-24-0 triisopropylsilyl chloride 
• 106412-35-5 N-benzyloxycarbonyl-2-piperidone 
• 501-53-1 benzyl chloroformate 
• 440677-09-8 [(E)-3-((2R,3R,5R)-5-Allyl-3-methyl-tetrahydro-furan-2-yl)-but-2-enyloxy]-triisopropyl-silane 
• 440677-11-2 3-[(2R,4R,5R)-4-Methyl-5-((E)-1-methyl-3-triisopropylsilanyloxy-propenyl)-tetrahydro-furan-2-yl]-propionaldehyde 
• 440677-10-1 3-[(2R,4R,5R)-4-Methyl-5-((E)-1-methyl-3-triisopropylsilanyloxy-propenyl)-tetrahydro-furan-2-yl]-propan-1-ol 
• 440677-12-3 {1-Methyl-4-[(2R,4R,5R)-4-methyl-5-((E)-1-methyl-3-triisopropylsilanyloxy-propenyl)-tetrahydro-furan-2-yl]-2-oxo-butyl}-phosphonic acid diethyl ester 
• 440677-05-4 (S)-5-[(E)-4-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-1-methylene-but-2-enyl]-dihydro-furan-2-one 
• 440677-22-5 (S)-5-[(E)-4-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-but-2-enoyl]-dihydro-furan-2-one 
• 440677-08-7 (E)-3-((2R,3R,5R)-5-Allyl-3-methyl-tetrahydro-furan-2-yl)-but-2-en-1-ol 
• 440677-20-3 (6R,7S)-8-Methyl-7-{(E)-2-methyl-5-[(2R,4R,5R)-4-methyl-5-((E)-1-methyl-3-triisopropylsilanyloxy-propenyl)-tetrahydro-furan-2-yl]-3-oxo-pent-1-enyl}-1-oxo-9-((S)-5-oxo-tetrahydro-furan-2-yl)-2-aza-spiro[5.5]undec-8-ene-2-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

Asymmetric construction of the azaspiro[5.5]undec-8-ene system towards gymnodimine synthesis

In the course of the synthetic studies on gymnodimine, a potent shellfish toxin, the asymmetric construction of the azaspirocyclic part was achieved by the (-)-siam·Cu(SbF6)2 complex catalyzed intermolecular Diels-Alder reaction in high exo- and enantioselectivities.