440677-36-1Relevant academic research and scientific papers
Enantioselective three-component synthesis of 4-arylated dehydroprolines: [3+2] annulation of allenylstannane and α-imino ester
Fuchibe, Kohei,Hatemata, Rina,Akiyama, Takahiko
, p. 8563 - 8566 (2005)
An enantioselective [3+2] annulation reaction of allenylstannane and α-imino ester was developed. Stille coupling of the resulting 4-stannyl dehydroproline gave optically active 4-arylated dehydroprolines in good yields.
One-pot synthesis of chiral dehydroproline esters: [3+2]-type cycloaddition reaction of allenylstannane and α-imino ester
Fuchibe, Kohei,Hatemata, Rina,Akiyama, Takahiko
, p. 11304 - 11310 (2007/10/03)
An enantioselective [3+2]-type cycloaddition of allenylstannane and α-imino ester was developed. Synthetic utility of the 4-stannyldehydroproline ester intermediate was demonstrated: iodine oxidation and Stille coupling reaction of the intermediate afforded optically active 4-iodo- and 4-aryldehydroproline esters in good yields and in high ees, respectively.
Catalytic, enantioselective propargyl- and allenylation reactions of α-imino ester
Kagoshima, Hirotaka,Uzawa, Tetsumaru,Akiyama, Takahiko
, p. 298 - 299 (2007/10/03)
Catalytic, enantioselective propargyl- and allenylation reactions of α-imino ester have been achieved by means of the [Cu(MeCN)4]ClO4/(R)-tol-BINAP catalyst to afford the corresponding propargyl- and allenyl-substituted α-amino acid
