441018-66-2

Upstream product

• 14618-80-5 (R)-benzyl glycidol 
• 79-08-3 bromoacetic acid 
• 167354-12-3 (2R)-1-(benzyloxy)-2-butanol 

Downstream Products

• 441018-69-5 (2S,3S)-2-[(R)-1-(benzyloxymethyl)propyl-1-oxy]-5-hexen-1,3-diol bis(tert-butyldimethylsilyl ether) 
• 441018-67-3 (4R)-3-[(2R,3S)-1-oxo-2-[(R)-1-(benzyloxymethyl)propyl-1-oxy]-3-hydroxy-5-hexenyl]-4-benzyl-1,3-oxazolidinone 
• 441018-65-1 (4R)-3-[1-oxo-2-[(R)-1-(benzyloxymethyl)propyl-1-oxy]ethyl]-4-benzyl-1,3-oxazolidinone 
• 441018-68-4 (2S,3S)-2-[(R)-1-(benzyloxymethyl)propyl-1-oxy]-5-hexen-1,3-diol 

Relevant academic research and scientific papers

Ring closing metathesis for the formation of medium ring ethers: The total synthesis of (-)-isolaurallene

The total synthesis of the marine metabolite (-)-isolaurallene is described. Two approaches to the core nine-membered ether are presented both of which are based on a ring closing metathesis to close the cyclic ether.