441024-69-7Relevant articles and documents
New pH-responsive gemini lipid derived co-liposomes for efficacious doxorubicin delivery to drug resistant cancer cells
Moitra, Parikshit,Kumar, Krishan,Sarkar, Sourav,Kondaiah, Paturu,Duan, Wei,Bhattacharya, Santanu
, p. 8184 - 8187 (2017)
A gemini version of the amphiphile palmitoyl homocysteine was synthesized. Co-liposomes were prepared using the gemini along with a natural zwitterionic lipid, DOPE and cholesterol at specified ratios. This afforded pH-responsive co-liposomes which could efficiently transport the anticancer drug, doxorubicin (DOX), across the DOX-resistant HeLa cancer cells in response to low pH of cellular endosomes.
Cationic gemini surfactants based on tartaric acid: Synthesis, aggregation, monolayer behaviour, and interaction with DNA
Buijnsters, Petrus J. J. A.,Garcia Rodriguez, Cristina L.,Willighagen, Egon L.,Sommerdijk, Nico A. J. M.,Kremer, Andreas,Camilleri, Patrick,Feiters, Martinus C.,Nolte, Roeland J. M.,Zwanenburg, Binne
, p. 1397 - 1406 (2007/10/03)
The synthesis of three novel cationic gemini surfactants (10, 12, and 14) based on tartaric acid appended with biocompatible palmitoyl tails and head groups is described, and their aggregation in water, monolayer behaviour, DNA binding, and gene transfect