441044-11-7

Basic information

• Product Name: 4-HYDROXY-PIPERIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER
• Synonyms: (2R,4R)-4-Hydroxy-1,2-piperidinedicarboxylic acid 1-(tert-butyl) ester;(2R,4R)-1-tert-Butoxycarbonyl-4-hydroxypiperidine-2-carboxylic aci
• CAS NO: 441044-11-7
• Molecular Formula: C11H19NO5
• Molecular Weight: 245.27
• Mol File: 441044-11-7.mol

Chemical Properties

• Appearance: /
• Density: 1.264
• CAS DataBase Reference: 4-HYDROXY-PIPERIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-HYDROXY-PIPERIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER(441044-11-7)
• EPA Substance Registry System: 4-HYDROXY-PIPERIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER(441044-11-7)

Safety Data

• Hazardous Substances Data: 441044-11-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-Hydroxy-piperidine-1,2-dicarboxylic acid 1-tert-butyl ester is used as a building block in the synthesis of pharmaceuticals for its versatile chemical properties and stability.
Used in Agrochemical Industry:
4-Hydroxy-piperidine-1,2-dicarboxylic acid 1-tert-butyl ester is used as a building block in the synthesis of agrochemicals to create effective compounds for agricultural applications.
Used in Organic Synthesis:
4-Hydroxy-piperidine-1,2-dicarboxylic acid 1-tert-butyl ester is used as a key intermediate in the synthesis of various fine chemicals due to its unique structure and reactivity.

Upstream product

• 441044-14-0 phenylmethanaminium (2R,4R)-1-(tert-butoxycarbonyl)-4-hydroxypiperidine-2-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 175671-49-5 (2R,4R)-4-hydroxy-2-piperidinecarboxylic acid 
• 1218818-60-0 1-phenylethylammonium (2R,4R)-1-(tert-butoxycarbonyl)-4-hydroxypiperidine-2-carboxylate 

Downstream Products

• 441044-14-0 phenylmethanaminium (2R,4R)-1-(tert-butoxycarbonyl)-4-hydroxypiperidine-2-carboxylate 
• 175671-49-5 (2R,4R)-4-hydroxy-2-piperidinecarboxylic acid 

Relevant articles and documents

TUBULYSIN ANALOGUES AS ANTICANCER AGENTS AND PAYLOADS FOR ANTIBODY-DRUG CONJUGATES AND METHODS OF TREATMENT THEREWITH

In one aspect, the present disclosure provides tubulysin analogs of the formula (I) wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect

Improved Total Synthesis of Tubulysins and Design, Synthesis, and Biological Evaluation of New Tubulysins with Highly Potent Cytotoxicities against Cancer Cells as Potential Payloads for Antibody-Drug Conjugates

Improved, streamlined total syntheses of natural tubulysins such as V (Tb45) and U (Tb46) and pretubulysin D (PTb-D43), and their application to the synthesis of designed tubulysin analogues (Tb44, PTb-D42, PTb-D47-PTb-D49, and Tb50-Tb120), are described.

INHIBITORS OF SPHINGOSINE KINASE 1

The invention relates to compounds of Formula (I). Compounds of the present invention are inliibitors of sphingosine kinase 3, and are useful in the treatment of various disorders and conditions, such as inflammatory disorders

Chemoenzymatic synthesis of the four diastereoisomers of 4-hydroxypipecolic acid from N-acetyl-(R,S)-allylglycine: Chiral scaffolds for drug discovery

All four diastereoisomers of 4-hydroxypipecolic acid were prepared in a form conveniently protected for drug discovery applications with the use of industrially scaleable methodology. Resolution of the racemic starting material using proprietary acylases followed by an acyliminium ion cyclisation gave diastereomeric mixtures of 4-formyloxypipecolic acid, which were differentiated using an enzyme-catalysed hydrolysis. The products were separated by partition, and by following a sequence of straightforward chemical steps, the individual stereoisomers of the protected 4-hydroxypipecolates were crystallized to optical purity in 100 g quantities.