441065-81-2Relevant academic research and scientific papers
Total asymmetric synthesis of a new 9,12-anhydroerythronolide aglycone
Gerber-Lemaire, Sandrine,Ainge, Simon W.,Glanzmann, Cecile,Vogel, Pierre
, p. 417 - 430 (2007/10/03)
Two novel, potentially antimicrobial erythronolide aglycon analogs ((-)-9 and (-)-30, respectively), which incorporate a large number of contiguous stereogenic centers, have been prepared by multistep synthesis from simple chirons. The chemistry presented demonstrates the power of the so-called 'naked sugars of the second generation' approach. As for the sporeamicins, our macrolides are 9,12-anhydroerythronolides, yet presenting a higher degree of complexity due to additional functional groups.
