441285-25-2

Upstream product

• 441285-24-1 (4S,5S,6R)-7-azido-5,6-bis-benzyloxy-hept-1-en-4-methanesulfonate 
• 1730-25-2 allylmagnesium bromide 
• 1058023-73-6 (3S,4R)-3,4-bis(benzyloxy)tetrahydrofuran-2-ol 
• 36199-02-7 3,4-di-O-benzyl-D-mannitol 
• 441285-22-9 (4S,5R,6R)-7-azido-5,6-bis-benzyloxy-hept-1-en-4-ol 
• 121964-09-8 (2R,3R,4R)-5-azido-3,4-bis-benzyloxy-pentane-1,2-diol 

Downstream Products

• 441285-20-7 (1R,2R,8aR)-1,2-bis-benzyloxy-2,3,8,8a-tetrahydro-1H-indolizidin-5-one 
• 125279-72-3 (1R,2R,8aR)-lentiginosine 
• 441285-21-8 (2'R,3'R,4'R)-1-(2'-allyl-3',4'-bis-benzyloxy-pyrrolidin-1'-yl)-propenone 

Relevant academic research and scientific papers

Synthesis of polyhydroxylated pyrrolidines from sugar-derived bromonitriles through a cascade addition of allylmagnesium bromide/cyclization/reduction

The synthesis of polyhydroxylated 2-allylpyrrolidines from sugar-derived bromonitriles in a cascade addition of allylmagnesium bromide/SN2 cyclization/reduction with Zn(BH4)2 is described. The stereochemical course of the

Total synthesis of (-)- and (+)-lentiginosine

Total synthesis of (-)-lentiginosine was achieved from D-mannitol using highly stereoselective reactions. Similarly, (+)-lentiginosine was synthesized from L-tartaric acid.