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Usage

Uses

Used in Organic Synthesis:
(3aR,7aR)-rel-5-Boc-hexahydro-1-oxo-furo[3,4-c]pyridine is used as a synthetic intermediate in organic synthesis for the preparation of a variety of complex organic molecules. Its unique structure and the presence of the Boc protecting group make it a valuable building block for the development of new chemical entities.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (3aR,7aR)-rel-5-Boc-hexahydro-1-oxo-furo[3,4-c]pyridine is utilized as a precursor for the synthesis of biologically active compounds. Its potential to be modified and functionalized allows for the exploration of its properties and applications in drug discovery, potentially leading to the development of new pharmaceuticals with novel mechanisms of action.
Used in Pharmaceutical Industry:
(3aR,7aR)-rel-5-Boc-hexahydro-1-oxo-furo[3,4-c]pyridine is used as a key intermediate in the pharmaceutical industry for the synthesis of drug candidates. Its unique structural features and the ability to protect the nitrogen atom with a Boc group make it an attractive candidate for the development of new therapeutic agents with improved pharmacological properties.
Used in Research and Development:
In research and development settings, (3aR,7aR)-rel-5-Boc-hexahydro-1-oxo-furo[3,4-c]pyridine serves as a valuable compound for studying the synthesis and properties of novel heterocycles. Its potential applications in various chemical and biological processes make it an important tool for advancing scientific knowledge and fostering innovation in the chemical and pharmaceutical industries.

Upstream product

• 577-58-2 cis-piperidine-3,4-dicarboxylic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 4741-42-8 furo<3,4-c>pyridin-1(3H)-one 
• 490-11-9 3,4-pyridinecarboxylic acid 

Relevant academic research and scientific papers

FUSED PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS

The invention relates to fused piperidine amides useful as inhibitors of ion channels for the treatment of pain. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

Synthesis of Fused Bicyclic Piperidines: Potential Bioactive Templates for Medicinal Chemistry

An array of six pyridyl-substituted fused bicyclic piperidines was prepared as novel cores for medicinal chemistry. For maximum diversity, the size of the fused ring varied from three to six atoms and contained up to two oxygen atoms. The pyridine ring was incorporated to improve physicochemical properties and to challenge the robustness of the chemistry. The presence of the pyridine did interfere with our initial approaches to these molecules, and in several instances, a blocking strategy had to be employed. These new scaffolds possess high sp3 character and may prove useful in multiple medicinal chemistry applications.

Synthesis and structure-activity relationship of a novel sulfone series of TNF-α converting enzyme inhibitors

Replacement of the amide functionality in IM491 (N-hydroxy-(5S,6S)-1- methyl-6-{[4-(2-methyl-4-quinolinylmethoxy)anilinyl]carbonyl} -5-piperidinecarboxamide) with a sulfonyl group led to a new series of α,β-cyclic and β,β-cyclic γ-sulfonyl hydroxamic acids, which were potent TNF-α converting enzyme (TACE) inhibitors. Among them, inhibitor 4b (N-hydroxy-(4S,5S)-1-methyl-5-{[4-(2-methyl-4- quinolinylmethoxy)phenyl]sulfonylmethyl}-4-pyrrolidinecarboxamide) exhibited IC50 values of 1 nM and 180 nM in porcine TACE (pTACE) and cell assays, respectively, with excellent selectivity over MMP-1, -2, -9 and -13 and was orally bioavailable with an F value of 46% in mice.