441351-28-6Relevant articles and documents
Fluorescent probe for fluorine ion detection, application of fluorescent probe and method for detecting fluorine ions in to-be-detected sample
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Paragraph 0070; 0074; 0080-0081, (2021/08/06)
The invention belongs to the technical field of analytical chemistry, and particularly relates to a fluorescent probe for fluorine ion detection, application of the fluorescent probe and a method for detecting fluorine ions in a to-be-detected sample. The invention provides a compound as shown in a formula I, or an optical isomer or salt thereof, and provides application of the compound as a fluorine ion detection fluorescent probe. According to the method for detecting the fluorine ions in the to-be-detected sample, the compound, or the optical isomer or the salt of the compound is used as a fluorine ion detection fluorescent probe for detection. The fluorescent probe has the advantages of good water solubility, high selectivity, high response speed, low detection limit, good stability, wide applicable pH range and good application prospect.
A novel HPQ-based turn-on fluorescent probe for detection of fluoride ions in living cells
Zhao, Zhou,Bi, Xinzhou,Mao, Wuxiang,Xu, Xiaowei
, p. 4129 - 4132 (2017/09/28)
2-(2′-Hydroxyphenyl)-4(3H)-quinazolinone (HPQ) has been reported as a precipitating fluorescent molecule with excellent optical properties, such as large Stokes shift and strong fluorescence intensity. HPQF, a novel HPQ-based turn-on probe for localizable detection of fluoride ions, was designed, synthesized and fully characterized by 1H NMR, 13C NMR and HRMS. As a chemogenic fluoride probe, the tert-butyldiphenylsilane moiety of HPQF can be easily cleaved by fluoride. After spontaneous 1,6-elimination, HPQ molecule was generated to emit fluorescence under the excitation light. Further study shows that HPQF exhibited high selectivity and sensitivity for detection of fluoride. In addition, HPQF was utilized for the detection of fluoride in living cells.
Homochiral oligomers with highly flexible backbones form stable H-bonded duplexes
Nú?ez-Villanueva, Diego,Hunter, Christopher A.
, p. 206 - 213 (2016/12/30)
Two homochiral building blocks featuring a protected thiol, an alkene and a H-bond recognition unit (phenol or phosphine oxide) have been prepared. Iterative photochemical thiol-ene coupling reactions were used to synthesize oligomers containing 1-4 phosphine oxide and 1-4 phenol recognition sites. Length-complementary H-bond donor and H-bond acceptor oligomers were found to form stable duplexes in toluene. NMR titrations and thermal denaturation experiments show that the association constant and the enthalpy of duplex formation increase significantly for every additional H-bonding unit added to the chain. There is an order of magnitude increase in stability for each additional H-bonding interaction at room temperature indicating that all of the H-bonding sites are fully bound to their complements in the duplexes. The backbone of the thiol-ene duplexes is a highly flexible alkane chain, but this conformational flexibility does not have a negative impact on binding affinity. The average effective molarity for the intramolecular H-bonding interactions that zip up the duplexes is 18 mM. This value is somewhat higher than the EM of 14 mM found for a related family of duplexes, which have the same recognition units but a more rigid backbone prepared using reductive amination chemistry. The flexible thiol-ene AAAA·DDDD duplex is an order of magnitude more stable than the rigid reductive amination AAAA·DDDD duplex. The backbone of the thiol-ene system retains much of its conformational flexibility in the duplex, and these results show that highly flexible molecules can make very stable complexes, provided there is no significant restriction of degrees of freedom on complexation.
