4415-09-2

Usage

InChI:InChI=1/C12H9ClFNO3/c1-6-9(12(16)17-2)11(15-18-6)10-7(13)4-3-5-8(10)14/h3-5H,1-2H3

Upstream product

• 387-45-1 2-chloro-6-fluorobenzaldehyde 
• 105-45-3 acetoacetic acid methyl ester 
• 51088-25-6 2-chloro-6-fluoro-N-hydroxybenzene-1-carbonimidoyl chloride 

Downstream Products

• 3919-74-2 3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid 
• 338417-50-8 methyl 3-(2-chloro-6-fluorophenyl)-5-(2-(dimethylamino)vinyl)isoxazole-4-carboxylate 
• 338966-53-3 methyl 3-(2-chloro-6-fluorophenyl)-5-(1-(dimethylamino)-4,4,4-trifluoro-3-oxobut-1-en-2-yl)isoxazole-4-carboxylate 
• 1391944-13-0 methyl 3-(2-chloro-6-fluorophenyl)-5-{[1-(4-methoxycarbonyl-3-(4-chlorophenyl)isoxazol-5-yl)-5-trifluoromethyl-1H-pyrazol-4-yl]}-isoxazole-4-carboxylate 
• 1391943-30-8 3-(2-chloro-6-fluorophenyl)-5-(1-(3-chlorophenyl)-5-(trifluoromethyl)-1H-pyrazol-4-yl)-N-methoxy-N-methylisoxazole-4-carboxamide 
• 1391943-36-4 3-(2-chloro-6-fluorophenyl)-5-(1-(3-chlorophenyl)-5-(trifluoromethyl)-1H-pyrazol-4-yl)isoxazole-4-carboxamide 
• 1391943-37-5 3-(2-chloro-6-fluorophenyl)-5-(1-(3-chlorophenyl)-5-(trifluoromethyl)-1H-pyrazol-4-yl)isoxazole-4-carboxylic acid 
• 1391943-38-6 (3-(2-chloro-6-fluorophenyl)-5-(1-(3-chlorophenyl)-5-(trifluoromethyl)-1H-pyrazol-4-yl)isoxazol-4-yl)(morpholino)methanone 
• 1391943-51-3 S-methyl 3-(2-chloro-6-fluorophenyl)-5-(1-(3-chlorophenyl)-5-(trifluoromethyl)-1H-pyrazol-4-yl)isoxazole-4-carbothioate 
• 1391944-16-3 3-(2-chloro-6-fluorophenyl)-5-(1-(3-chlorophenyl)-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4-(thiazol-2-yl)isoxazole 
• 1391944-18-5 3-(2-chloro-6-fluorophenyl)-5-(1-(3-chlorophenyl)-5-(trifluoromethyl)-1H-pyrazol-4-yl)isoxazole-4-carbothioamide 
• 1391944-22-1 methyl 3-(2-chloro-6-fluorophenyl)-5-(1-(2,4-difluorophenyl)-5-(trifluoromethyl)-1H-pyrazol-4-yl)isoxazole-4-carboxylate 
• 1391944-26-5 3-(2-chloro-6-fluorophenyl)-5-(1-(3-chlorophenyl)-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4-(oxazol-5-yl)isoxazole 
• 1391944-29-8 C₂₀H₉Cl₂F₄N₃O₂ 

Relevant academic research and scientific papers

Synthesis of 1,2,3-triazole substituted isoxazoles via copper (I) catalyzed cycloaddition

The synthesis of a series of 3,5-disubstituted isoxazole-4-carboxylic esters containing N-substituted 1,2,3-triazoles (V) starting from various benzaldehydes (I) is reported. Benzaldehydes undergo oximation with hydroxylamine hydrosulfate. Later, chlorination followed by condensation with methylacetoacetate and the hydrolysis of the resulting ester afforded respective carboxylic acid (II), which on chlorination with PCl5 gave the corresponding acid chlorides (III). The coraboxylic acid chlorides (III) on propargylation gave propargylic esters (IV) and these on click reaction gave the title compounds (V).