4415-84-3

Basic information

• Product Name: CYCLOBUTANEPROPANOIC ACID
• Synonyms: CYCLOBUTANEPROPANOIC ACID;3-cyclobutylpropanoic acid(SALTDATA: FREE);3-cyclobutylpropanoic acid;3-CYCLOBUTANEPROPANOIC ACID
• CAS NO: 4415-84-3
• Molecular Formula: C₇H₁₂O₂
• Molecular Weight: 128.16898
• Mol File: 4415-84-3.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: CYCLOBUTANEPROPANOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: CYCLOBUTANEPROPANOIC ACID(4415-84-3)
• EPA Substance Registry System: CYCLOBUTANEPROPANOIC ACID(4415-84-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 4415-84-3(Hazardous Substances Data)

Usage

Uses

3-Cyclobutylpropanoic Acid is used in preparation of substituted Oxopyridine derivatives as factor XIa and plasma kallikrein inhibitors.

Upstream product

• 14085-86-0 3-cyclobutylpropanenitrile 
• 21782-47-8 ethyl 3-cyclobutyl-2-ethoxycarbonylpropionate 
• 1010422-67-9 2-cyclobutylmethyl malonic acid 
• 36206-72-1 2-cyclobutylethyl 4-methylbenzenesulfonate 
• 13295-53-9 cyclobutylmethyl 4-methylbenzenesulfonate 
• 17247-58-4 (Bromomethyl)cyclobutane 
• 4415-82-1 cyclobutanemethanol 

Downstream Products

• 21782-48-9 3-(cyclobutyl)-1-propanol 
• 1455038-64-8 1-(5-(7-chloro-2-methyl-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)-3-(2-cyclobutylethyl)urea 
• 71037-57-5 3-Cyclobutyl-propionyl chloride 

Relevant articles and documents

QUINOLINE DERIVATIVES AS INHIBITORS OF AXL/MER RTK AND CSF1R

The present invention relates to quinoline derivatives which are inhibitors for Axl/Mer RTK (receptor tyrosine kinase) and CSF1R (colony stimulating factor 1 receptor). These compounds are suitable for the treatment of disorders associated with, accompanied by, caused by or induced by Axl/Mer RTK and CSF1R, in particular a hyperfunction thereof. The compounds are suitable for the treatment of hyperproliferative disorders, such as cancer, particularly immune-suppressive cancer (such as those cancers with an immunosuppression of innate immunity in a tumor microenvironment (TME), refractory cancer and cancer metastases. They are also useful in the treatment of inflammatory diseases and/or neurodegenerative diseases.

Practical synthesis of a peptide deformylase (PDF) inhibitor

A practical chromatography-free synthesis of an N-formylated hydroxylamine peptide deformylase inhibitor LCD320 is described. A diastereoselective Michael reaction of (4S)-3-[2-(cyclobutylmethyl)-l-oxo-2-propenyl]-4-(phenylmethyl)-2- oxazolidinone with 0-benzyl hydroxylamine was used to establish the key stereogenic center. We found that traces of residual Li+ from a previous step had a great impact on the diastereoselectivity of this reaction. A very efficient amidalion coupling reaction of proline derivative (2S,4R)-4-fluoro-1,2-m-pyrrolidinedicarboxylic acid 1,1-dimethylethyl ester with weakly nucleophilic 3-pyridazinamine using methanesulfonyl chloride in the presence of l-methylimidazole in DMF was also developed that proceeded without racemization.

Structure activity relations in acids related to cyclobutanecarboxylic acid

-