4416-71-1

Basic information

• Product Name: 3-Methyl-4-phenylisoxazol-5-amine
• Synonyms: 3-methyl-4-phenylisoxazol-5-amine(SALTDATA: FREE)
• CAS NO: 4416-71-1
• Molecular Formula: C₁₀H₁₀N₂O
• Molecular Weight: 174.2
• Mol File: 4416-71-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 315.4°C at 760 mmHg
• Flash Point: 144.6°C
• Appearance: /
• Density: 1.166g/cm³
• Vapor Pressure: 0.000437mmHg at 25°C
• Refractive Index: 1.588
• CAS DataBase Reference: 3-Methyl-4-phenylisoxazol-5-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Methyl-4-phenylisoxazol-5-amine(4416-71-1)
• EPA Substance Registry System: 3-Methyl-4-phenylisoxazol-5-amine(4416-71-1)

Safety Data

• Hazardous Substances Data: 4416-71-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H10N2O/c1-7-9(10(11)13-12-7)8-5-3-2-4-6-8/h2-6H,11H2,1H3

Upstream product

• 1071612-78-6 C₉H₈N₂ 
• 7063-95-8 acetonitrile-N-oxide 
• 140-29-4 phenylacetonitrile 
• 58377-56-3 Z α-phenyl β-nitrocrotononitrile 
• 4468-48-8 1-phenyl-1-cyanopropan-2-one 

Downstream Products

• 17601-48-8 (3-methyl-4-phenyl-isoxazol-5-yl)-piperidin-1-ylmethyl-amine 
• 99067-93-3 3-amino-2-phenyl-crotonic acid amide 
• 29879-48-9 3-methyl-4-phenyl-2H-isoxazol-5-one 

Relevant articles and documents

Enantioselective dearomative [3+2] annulation of 5-amino-isoxazoles with quinone monoimines

The first enantioselective dearomative [3+2] annulation of 5-amino-isoxazoles with quinone monoimines was realized using a chiral phosphoric acid as catalyst. Various novel (bridged) isoxazoline fused dihydrobenzofurans bearing two continuous quaternary stereocenters were achieved in moderate to good yields (up to 94%) with moderate to good enantioselectivities (up to 98% ee). The absolute configurations of two products were assigned by X-ray crystal structural analyses and a plausible reaction mechanism was proposed. This journal is

Efficient regioselective synthesis of 4- and 5-substituted isoxazoles under thermal and microwave conditions

(Chemical Equation Presented) The [2+3] cycloaddition reaction between nitrile oxides 2 and the captodative olefins 1 or the methyl crotonate derivatives 4 is regioselective and leads to the formation of the 5-substituted amino-isoxazole 3 or the 4-substi