4416-71-1Relevant academic research and scientific papers
Enantioselective dearomative [3+2] annulation of 5-amino-isoxazoles with quinone monoimines
Liu, Hui,Yan, Yingkun,Zhang, Jiayan,Liu, Min,Cheng, Shaobing,Wang, Zhouyu,Zhang, Xiaomei
supporting information, p. 13591 - 13594 (2020/11/17)
The first enantioselective dearomative [3+2] annulation of 5-amino-isoxazoles with quinone monoimines was realized using a chiral phosphoric acid as catalyst. Various novel (bridged) isoxazoline fused dihydrobenzofurans bearing two continuous quaternary stereocenters were achieved in moderate to good yields (up to 94%) with moderate to good enantioselectivities (up to 98% ee). The absolute configurations of two products were assigned by X-ray crystal structural analyses and a plausible reaction mechanism was proposed. This journal is
Human carbonic anhydrase inhibitory profile of mono- and bis-sulfonamides synthesized via a direct sulfochlorination of 3- and 4-(hetero)arylisoxazol-5-amine scaffolds
Krasavin, Mikhail,Korsakov, Mikhail,Zvonaryova, Zhanna,Semyonychev, Evgenii,Tuccinardi, Tiziano,Kalinin, Stanislav,Tan?, Muhammet,Supuran, Claudiu T.
, p. 1914 - 1925 (2017/03/08)
Three distinct series of isoxazole-based primary mono- and bis-sulfonamides have been synthesized via direct sulfochlorination, each of them delivering nanomolar inhibitors of human carbonic anhydrase. Certain pronounced SAR trends have been established a
Efficient regioselective synthesis of 4- and 5-substituted isoxazoles under thermal and microwave conditions
Lasri, Jamal,Mukhopadhyay, Suman,Charmier, M. Adilia Januario
experimental part, p. 1385 - 1389 (2009/04/10)
(Chemical Equation Presented) The [2+3] cycloaddition reaction between nitrile oxides 2 and the captodative olefins 1 or the methyl crotonate derivatives 4 is regioselective and leads to the formation of the 5-substituted amino-isoxazole 3 or the 4-substi
Preparation de β-alcoxy acrylonitriles et d'amino-5 isoxazoles a partir d'α-cyano β-nitro-styrenes et -stilbenes
Colau, Roger,Viel, Claude
, p. 163 - 167 (2007/10/02)
Previously we have examined the action of amines on Z α-cyano β-nitrostilbenes (1).We now would like to report the results of our studies on the action of two other nucleophiles (alcohols and thiols) on these stilbenes derivatives.At room temperature in a
