441713-54-8

Basic information

• Product Name: methyl 4-(4,4-difluoro-1-(2-(2-methylphenylamino)-6-benzoxazolylacetyl)-(2S)-pyrrolidinylmethoxy)benzoate
• Synonyms: methyl 4-(4,4-difluoro-1-(2-(2-methylphenylamino)-6-benzoxazolylacetyl)-(2S)-pyrrolidinylmethoxy)benzoate
• CAS NO: 441713-54-8
• Molecular Weight: 535.547
• Mol File: 441713-54-8.mol

Chemical Properties

• CAS DataBase Reference: methyl 4-(4,4-difluoro-1-(2-(2-methylphenylamino)-6-benzoxazolylacetyl)-(2S)-pyrrolidinylmethoxy)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-(4,4-difluoro-1-(2-(2-methylphenylamino)-6-benzoxazolylacetyl)-(2S)-pyrrolidinylmethoxy)benzoate(441713-54-8)
• EPA Substance Registry System: methyl 4-(4,4-difluoro-1-(2-(2-methylphenylamino)-6-benzoxazolylacetyl)-(2S)-pyrrolidinylmethoxy)benzoate(441713-54-8)

Safety Data

• Hazardous Substances Data: 441713-54-8(Hazardous Substances Data)

Upstream product

• 256453-94-8 2-(2-methylphenylamino)-6-benzoxazolylacetic acid 

Downstream Products

• 441711-88-2 4-(4,4-difluoro-1-(2-(2-methylphenylamino)-6-benzoxazolylacetyl)-2S-pyrrolidinylmethoxy)benzoic acid 

Relevant articles and documents

VLA-4 INHIBITORS

The present invention relates to a compound represented by the following formula (I): (wherein, W represents WA-A1 -WB - (in which, WA is substituted or unsubstituted aryl, etc., A1 is -NR1-, single bond, -C(O)-, etc., and WB is substituted or unsubstituted arylene, etc.), R is single bond, -NH-, -OCH2-, alkenylene, etc., X is -C(O) -CH2-, etc., and M is, for example, the following formula: (in which, R11, R12 and R13 each independently represents hydrogen, hydroxyl, amino, halogen, etc., R14 is hydrogen or lower alkyl, Y represents -CH2-O-, etc., Z is substituted or unsubstituted arylene, etc., A2 is single bond, etc, and R10 is hydroxyl or lower alkoxy)), or salt thereof; and a medicament containing the same. This compound or salt thereof selectively inhibits binding of cell adhesion molecules to VAL-4 and exhibits high bioavailability so that it is useful as a preventive and/or remedy for inflammatory diseases, autoimmune diseases, metastasis, bronchial asthma, rhinostenosis, diabetes, and the like.