441714-09-6

Basic information

• Product Name: (Z)-(2S)-(4-benzyloxy-2-butenyloxy)methyl-1-(tert-butoxycarbonyl)-(4S)-fluoropyrrolidine
• Synonyms: (Z)-(2S)-(4-benzyloxy-2-butenyloxy)methyl-1-(tert-butoxycarbonyl)-(4S)-fluoropyrrolidine
• CAS NO: 441714-09-6
• Molecular Weight: 379.472
• Mol File: 441714-09-6.mol

Chemical Properties

• CAS DataBase Reference: (Z)-(2S)-(4-benzyloxy-2-butenyloxy)methyl-1-(tert-butoxycarbonyl)-(4S)-fluoropyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-(2S)-(4-benzyloxy-2-butenyloxy)methyl-1-(tert-butoxycarbonyl)-(4S)-fluoropyrrolidine(441714-09-6)
• EPA Substance Registry System: (Z)-(2S)-(4-benzyloxy-2-butenyloxy)methyl-1-(tert-butoxycarbonyl)-(4S)-fluoropyrrolidine(441714-09-6)

Safety Data

• Hazardous Substances Data: 441714-09-6(Hazardous Substances Data)

Upstream product

• 89358-30-5 (Z)-(((4-bromobut-2-en-1-yl)oxy)methyl)benzene 
• 317356-27-7 tert-butyl (2S,4S)-4-fluoro-2-(hydroxymethyl)pyrrolidine-1-carboxylate 
• 311-28-4 tetra-(n-butyl)ammonium iodide 

Relevant articles and documents

A novel and potent VLA-4 antagonist based on trans-4-substituted cyclohexanecarboxylic acid

During the course of our study, it was revealed that the poor pharmacokinetic properties of a series of benzoic acid derivatives such as 1 should be attributed to the diphenylurea moiety. Thus, we replaced the diphenylurea moiety in 1 with a 2-(2-methylphenylamino)benzoxazole moiety which mimics the diphenylurea structure. However, this modification resulted in a significant decrease (3, IC50 = 19 nM) in VLA-4 inhibitory activity compared to 1 (IC50 = 1.6 nM). To address this discrepancy, we worked on optimization of the carboxylic acid moiety in compound 3. As a result, our efforts have led to the discovery of trans-4-substituted cyclohexanecarboxylic acid derivative 11b (IC50 = 2.8 nM) as a novel and potent VLA-4 antagonist. In addition, compound 11b exhibited favorable pharmacokinetic properties (CL = 3.3 ml/min/kg, F = 51%) in rats.

VLA-4 INHIBITORS

The present invention relates to a compound represented by the following formula (I): (wherein, W represents WA-A1 -WB - (in which, WA is substituted or unsubstituted aryl, etc., A1 is -NR1-, single bond, -C(O)-, etc., and WB is substituted or unsubstituted arylene, etc.), R is single bond, -NH-, -OCH2-, alkenylene, etc., X is -C(O) -CH2-, etc., and M is, for example, the following formula: (in which, R11, R12 and R13 each independently represents hydrogen, hydroxyl, amino, halogen, etc., R14 is hydrogen or lower alkyl, Y represents -CH2-O-, etc., Z is substituted or unsubstituted arylene, etc., A2 is single bond, etc, and R10 is hydroxyl or lower alkoxy)), or salt thereof; and a medicament containing the same. This compound or salt thereof selectively inhibits binding of cell adhesion molecules to VAL-4 and exhibits high bioavailability so that it is useful as a preventive and/or remedy for inflammatory diseases, autoimmune diseases, metastasis, bronchial asthma, rhinostenosis, diabetes, and the like.