441764-60-9

Basic information

• Product Name: (R)-2-(2-cyclohexylaino-ethoxy)-succinic acid dimethyl ester
• Synonyms: (R)-2-(2-cyclohexylaino-ethoxy)-succinic acid dimethyl ester
• CAS NO: 441764-60-9
• Molecular Weight: 287.356
• Mol File: 441764-60-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-2-(2-cyclohexylaino-ethoxy)-succinic acid dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-(2-cyclohexylaino-ethoxy)-succinic acid dimethyl ester(441764-60-9)
• EPA Substance Registry System: (R)-2-(2-cyclohexylaino-ethoxy)-succinic acid dimethyl ester(441764-60-9)

Safety Data

• Hazardous Substances Data: 441764-60-9(Hazardous Substances Data)

Upstream product

• 441764-51-8 (R)-2-allyloxysuccinic acid dimethyl ester 
• 70681-41-3 (R)-dimethyl malate 
• 108-91-8 cyclohexylamine 
• 441764-53-0 (R)-2-(2-oxo-ethoxy)-succinic acid dimethyl ester 

Relevant articles and documents

Novel morpholinone-based D-Phe-Pro-Arg mimics as potential thrombin inhibitors: design, synthesis, and X-ray crystal structure of an enzyme inhibitor complex.

A morpholinone structural motif derived from D(+)- and L(-)-malic acid has been used as a mimic of D-Phe-Pro in the thrombin inhibiting tripeptide D-Phe-Pro-Arg. In place of Arg the more rigid P1 truncated p-amidinobenzylamine (Pab) or 2-amino-5-aminomethyl-3-methyl-pyridine have been utilized. The synthetic strategy developed readily delivers these novel thrombin inhibitors used to probe the alpha-thrombin inhibitor binding site. The best candidate in this series of thrombin inhibitors exhibits an in vitro IC(50) of 720 nM. The X-ray crystal structure of this candidate co-crystallized with alpha-thrombin is discussed.