441775-35-5Relevant academic research and scientific papers
Chain-growth polyglycosylation: Synthesis of linker-equipped mannosyl oligomers
Schuster, Heiko J.,Vijayakrishnan, Balakumar,Davis, Benjamin G.
, p. 135 - 141 (2015)
Direct syntheses of acetylated poly-mannosides can be achieved in one-step starting from a fully acetylated thioglycoside mannosyl donor using a polymerization-type strategy under the correct conditions. Under conditions that allow polymer growth from non-reducing to reducing end (N→R), different acceptor alcohols can be used as the 'terminating acceptors' to install different linkers at the reducing terminus. The efficiency is dependent on substituents of the linker, its length, temperature and choice of Lewis acid activator.
Analysis of the dispersity in carbohydrate loading of synthetic glycoproteins using MALDI-TOF mass spectrometry
Patel, Mitul K.,Vijayakrishnan, Balakumar,Koeppe, Julia R.,Chalker, Justin M.,Doores, Katie J.,Davis, Benjamin G.
supporting information; experimental part, p. 9119 - 9121 (2011/02/23)
Statistical correlation of mass spectrum peak broadening with product dispersity in protein conjugation reactions allows more detailed characterization of putative therapeutic conjugates.
Efficient preparation of glycoclusters from silsesquioxanes
Gao, Yongjun,Eguchi, Atsuko,Kakehi, Kazuaki,Lee, Yuan C.
, p. 3457 - 3460 (2007/10/03)
(Chemical Equation Presented) A new type of glycocluster based on polyhedral oligosilsesquioxanes (POSS) has been efficiently prepared from unprotected mannoside and lactoside employing a convergent approach of thiol-radical addition reaction. The versatility of this approach was demonstrated by functionalization of mannosides and lactosides of different-length spacers.
