441777-48-6

Basic information

• Product Name: 4-Heptynoicacid,2-amino-,methylester(9CI)
• Synonyms: 4-Heptynoicacid,2-amino-,methylester(9CI)
• CAS NO: 441777-48-6
• Molecular Formula: C₈H₁₃NO₂
• Molecular Weight: 155.19
• Product Categories: GLYCINESCAFFOLD
• Mol File: 441777-48-6.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Heptynoicacid,2-amino-,methylester(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Heptynoicacid,2-amino-,methylester(9CI)(441777-48-6)
• EPA Substance Registry System: 4-Heptynoicacid,2-amino-,methylester(9CI)(441777-48-6)

Safety Data

• Hazardous Substances Data: 441777-48-6(Hazardous Substances Data)

Upstream product

• 6261-22-9 pent-2-yn-1-ol 
• 16400-32-1 1-bromo-pent-2-yne 
• 441777-47-5 methyl 2-[(diphenylmethylene)amino]hept-4-ynoate 

Downstream Products

• 216988-59-9 methyl 5-ethyl-4-iodo-1-(4-tolylsulfonyl)-2,3-dihydropyrrole-2-carboxylate 
• 216988-55-5 methyl 2-(4-tolylsulfonylamino)hept-4-ynoate 

Relevant articles and documents

Rhodium(I)-catalyzed cycloisomerization reaction of yne-allenamides: An approach to cyclic enamides

In this paper, we demonstrate a successful conversion of alkynyl allenamides to triene-containing heterocycles via a rhodium(I)-catalyzed cycloisomerization reaction. Georg Thieme Verlag Stuttgart.

An approach to 2,3-dihydropyrroles and β-iodopyrroles based on 5-endo-dig cyclisations

A representative series of homopropargylic sulfonamides 19 and 22b have been found to undergo smooth 5-endo-dig cyclisation upon exposure to excess iodine in acetonitrile containing potassium carbonate. The resulting 4-iodo-2,3-dihydropyrroles 23 readily react with two equivalents of DBU in DMF at 20°C to give the corresponding β-iodopyrroles 24 and 26 in excellent yields by the elimination of toluene-p-sulfinic acid. Use of less than two equivalents of base results in some loss of iodine. The iodo-2,3-dihydropyrroles 23 can be used in palladium-catalysed coupling reactions as shown by the efficient formation of the Sonogashira product 29 under mild conditions.

5-Endo-dig cyclisations of homopropargylic sulfonamides: A new route to 2,3-dihydropyrroles and β-iodopyrroles

5-endo-dig Iodocyclisations of the homopropargylic sulfonamides 12a-c and 13 give excellent yields of the iododihydropyrroles 14a-d and thence the β-iodopyrroles 15a-d, following base-catalysed elimination of sulfinic acid.