4421-09-4

Basic information

• Product Name: Piperonylonitrile
• Synonyms: 5-Cyano-1,3-benzodioxole;Piperonylonitrile, 97% 25GR;3,4-Methylenedioxy benzonitrile (Piperonyl Nitrile);Piperonylonitrile 97%;3,4-Methylenedioxy benzonitrile Piperonylonitrile;2H-1,3-benzodioxole-5-carbonitrile;AKOS B004105;AKOS 214-97
• CAS NO: 4421-09-4
• Molecular Formula: C₈H₅NO₂
• Molecular Weight: 147.13
• EINECS: 224-590-6
• Product Categories: Benzodiozoles, Benzodioxines & Benzodioxepines;Benzodiozoles, Benzodioxines & Benzodioxepines;Aromatic Esters
• Mol File: 4421-09-4.mol
• Article Data: 143

Chemical Properties

• Melting Point: 91-93 °C(lit.)
• Boiling Point: 267.22°C (rough estimate)
• Flash Point: 115.4 °C
• Appearance: White to beige/Crystalline Powder or Needles
• Density: 1.3067 (rough estimate)
• Vapor Pressure: 0.0146mmHg at 25°C
• Refractive Index: 1.5510 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Dichloromethane, Ethyl Acetate, Methanol
• BRN: 6224
• CAS DataBase Reference: Piperonylonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: Piperonylonitrile(4421-09-4)
• EPA Substance Registry System: Piperonylonitrile(4421-09-4)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 20/21/22-20/21
• Safety Statements: 36-23-24/25
• RIDADR: 3276
• WGK Germany: 3
• RTECS: TO2645000
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 4421-09-4(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 4421-09-4 differently. You can refer to the following data:
1. A methylenedioxyphenyl (MDP) compound. Inhibitor of nasal P 450-dependent N-demethylase in rabbits. Toxic against D. farinae, D. pteronyssinus, and T. putrescentiae.
2. Piperonylonitrile has been used to alter the growth of Nif + and Nif - strains of K.pneumoniae.

InChI:InChI=1/C8H5NO2/c9-4-6-1-2-7-8(3-6)11-5-10-7/h1-3H,5H2

Upstream product

• 120-57-0 piperonal 
• 2635-13-4 1,2-(methylenedioxy)-4-bromobenzene 
• 214783-17-2 5-(azidomethyl)benzo[d][1,3]dioxole 
• 4720-72-3 N′-hydroxybenzo[d][1,3]dioxole-5-carboximidamide 
• 5354-08-5 5-(methylthio)benzo[d][1,3]dioxole 
• 100-47-0 benzonitrile 
• 455-18-5 4-CF₃C₆H₄CN 
• 68-12-2 N,N-dimethyl-formamide 
• 2861-28-1 1,3-benzodioxole-5-acetic acid 
• 7228-38-8 5-chloro-1,3-benzodioxole 
• 57-13-6 urea 
• 124-38-9 carbon dioxide 
• 14906-59-3 4-cyanopyridine N-oxide 
• 630-18-2 tert-butyl isocyanide 

Downstream Products

• 248249-56-1 2-(benzo[3,4-d]1,3-dioxolan-5-yl)-4-hydroxymethyl-1,3-thiazole 
• 248249-53-8 ethyl 4-(benzo[3,4-d]1,3-dioxolan-5-yl)-3,5-thiazole carboxylate 
• 184036-18-8 N-(4-chloro-3-methyl-5-isoxazolyl)-2-{[2-cyano-4,5-(methylenedioxy)phenyl]aminocarbonyl}thiophene-3-sulfonamide 
• 177662-30-5 5-[1-[4-(methylsulfonyl)phenyl]-4-hydroxy-4-(trifluoromethyl)-4,5-dihydro-1H-imidazol-2-yl]-1,3-benzodioxole 
• 2620-50-0 1,3-benzodioxol-5-ylmethyl amine 
• 41230-20-0 2-(benzo[1,3]dioxol-5-yl)-1,3-benzothiazole 
• 6701-35-5 bis(benzo[d][1,3]dioxol-5-ylmethyl)amine 
• 82-85-9 benzo[1,3]dioxol-5-yl-(2-hydroxy-4,6-dimethoxy-phenyl)-ketone 
• 17345-61-8 3,4-dihydroxybenzonitrile 
• 177662-29-2 3,4-methylenedioxy-N-[4-(methylsulfonyl)phenyl]benzenecarboximidamide 
• 3162-29-6 1-(benzo[d][1,3]dioxol-6-yl)ethanone 
• 94-53-1 Piperonylic acid 
• 118128-85-1 C-Benzo[1,3]dioxol-5-yl-C-[2,3-dimethoxy-6-(2-methyl-[1,3]dioxolan-2-ylmethyl)-phenyl]-methyleneamine 
• 145102-01-8 3-hydroxy-4-(propylthio)benzonitrile 

Relevant articles and documents

Cu2O-Catalyzed Conversion of Benzyl Alcohols Into Aromatic Nitriles via the Complete Cleavage of the C≡N Triple Bond in the Cyanide Anion

Nitrogen transfer from cyanide anion to an aldehyde is emerging as a promising method for the synthesis of aromatic nitriles. However, this method still suffers from a disadvantage that a use of stoichiometric Cu(II) or Cu(I) salts is required to enable the reaction. As we report herein, we overcame this drawback and developed a catalytic method for nitrogen transfer from cyanide anion to an alcohol via the complete cleavage of the C≡N triple bond using phen/Cu2O as the catalyst. The present condition allowed a series of benzyl alcohols to be smoothly converted into aromatic nitriles in moderate to high yields. In addition, the present method could be extended to the conversion of cinnamic alcohol to 3-phenylacrylonitrile.

Imidazole hydrochloride promoted synthesis of 3,5-disubstituted-1,2,4-oxadiazoles

Imidazole hydrochloride as an additive promotes the reaction of amidoximes and DMA derivatives to generated 3,5-disubstituted-1,2,4-oxadiazoles in low to excellent yields without the use of coupling reagents, oxidants, strong acids or bases and other additives.

Revisiting the synthesis of aryl nitriles: a pivotal role of CAN

Facilitated by the dual role of Ceric Ammonium Nitrate (CAN), herein we report a cost-effective approach for the cyanation of aryl iodides/bromides with CAN-DMF as an addition to the existing pool of combined cyanation sources. In addition to being an oxidant, CAN acts as a source of nitrogen in our protocol. The reaction is catalyzed by a readily available Cu(ii) salt and the ability of CAN to generate ammonia in the reaction medium is utilized to eliminate the additional requirement of a nitrogen source, ligand, additive or toxic reagents. The mechanistic study suggests an evolution of CN?leading to the synthesis of a variety of aryl nitriles in moderate to good yields. The proposed mechanism is supported by a series of control reactions and labeling experiments.