442125-30-6

Basic information

• Product Name: (4-TRIFLUOROMETHYLPHENOXY) ACETIC ACID ETHYL ESTER
• Synonyms: (4-TRIFLUOROMETHYLPHENOXY) ACETIC ACID ETHYL ESTER
• CAS NO: 442125-30-6
• Molecular Formula: C₁₁H₁₁F₃O₃
• Molecular Weight: 248.2
• Mol File: 442125-30-6.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (4-TRIFLUOROMETHYLPHENOXY) ACETIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (4-TRIFLUOROMETHYLPHENOXY) ACETIC ACID ETHYL ESTER(442125-30-6)
• EPA Substance Registry System: (4-TRIFLUOROMETHYLPHENOXY) ACETIC ACID ETHYL ESTER(442125-30-6)

Safety Data

• Hazardous Substances Data: 442125-30-6(Hazardous Substances Data)

Usage

General Description

(4-Trifluoromethylphenoxy) acetic acid ethyl ester is a chemical compound with the molecular formula C10H9F3O3. It is an ester of (4-trifluoromethylphenoxy) acetic acid and is commonly used as a herbicide and plant growth regulator. This chemical is known to selectively control the growth of broadleaf weeds in various crops. It works by mimicking the action of auxin, a plant hormone, and disrupting the normal growth and development of weeds. (4-Trifluoromethylphenoxy) acetic acid ethyl ester is an important tool in agrochemicals for managing weed populations and maintaining crop yields.

Upstream product

• 402-45-9 4-hydroxybenzotrifluoride 
• 105-36-2 ethyl bromoacetate 
• 105-39-5 chloroacetic acid ethyl ester 

Downstream Products

• 860649-71-4 4-trifluoromethylphenoxyacetic acid hydrazide 
• 67273-84-1 2-[4-(trifluoromethyl)phenoxy]acetyl chloride 
• 1401223-06-0 N-((3-(4-chlorophenyl)-1,2,4-oxadiazol-5-yl)methyl)-N-isopropyl-2-(4-(trifluoromethyl)phenoxy)acetamide 
• 1401223-05-9 N-isopropyl-2-(4-(trifluoromethyl)phenoxy)-N-((3-(4-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)methyl)acetamide 
• 1401223-04-8 N-isopropyl-N-((3-phenyl-1,2,4-oxadiazol-5-yl)methyl)-2-(4-(trifluoromethyl)phenoxy)acetamide 
• 1401223-03-7 N-isopropyl-N-((3-p-tolyl-1,2,4-oxadiazol-5-yl)methyl)-2-(4-(trifluoromethyl)phenoxy)acetamide 
• 163839-73-4 2-(4-(trifluoromethyl)phenoxy)acetic acid 

Relevant articles and documents

Identification and synthesis of selective cholesterol esterase inhibitor using dynamic combinatorial chemistry

In this study, the concept of dynamic combinatorial chemistry (DCC) was applied to explore novel cholesterol esterase (CEase) inhibitors. In the presence of enzyme, two substrates (A1H3 and A2H3) were amplified from the dynamic combinatorial library (DCL), which was generated through reversible acylhydrazone formation reaction. In the in vitro biological evaluation, compound A1H3 exhibited not only potent (IC50 in nanomolar range) but also selective inhibition (>120 folds of selectivity for CEase over AChE). Furthermore, the binding pattern and possible binding mechanism were investigated in the kinetic experiment and molecular docking study, respectively.

Synthesis, Nematicidal Activity, and 3D-QSAR of Novel 1,3,4-Oxadiazole/ Thiadiazole Thioether Derivatives

Forty one novel 1,3,4-oxadiazole/thiadiazole thioether derivatives containing phenoxy moiety were designed and synthesized. Bioassay demonstrated that some of them showed remarkable activities against Tylenchulus semipenetrans in vitro and in vivo. Compounds 20, 21, 35 and 39 showed excellent lethal activities after treatment for 48?h in vitro, with LC50 values of 13.4?±?1.8, 11.7?±?2.5, 13.7?±?2.4 and 13.3?±?1.1?mg·L–1, respectively, which were obviously superior to fosthiazate (49.1?±?2.8?mg·L–1) and avermectin (26.6?±?2.3?mg·L–1). Compound 21 can effectively control the citrus nematode disease caused by T. semipenetrans at 200?mg·L–1 in vivo with (68?±?3)% inhibitory effect, which was even better than that of avermectin ((63?±?2)%). The CoMFA and CoMSIA models of three-dimensional quantitative structure-activity relationships (3D-QSARs) were established. The compound 33 was designed based on the 3D-QSAR models with more vigorous nematicidal activities in vitro (LC50?=?9.8?±?1.4?mg·L–1) and in vivo ((70?±?5)%). These results demonstrated that compound 33 can be considered as a potential nematicide.

Synthesis and biological activity of 1-(Substituted phenoxyacetoxy)- 1-(pyridin-2-yl or thien-2-yl)methylphosphonates

A series of novel O,O-dimethyl 1-(substituted phenoxyacetoxy)-1-(pyridin-2-yl or thien-2-yl)methylphosphonates 6a-n and 7a-d were synthesized. Their structures were confirmed by IR, 1H NMR, mass spectroscopy, and elemental analyses. The results of preliminary bioassays show that some of the title compounds exhibit moderate to good herbicidal and fungicidal activities. For example, the title compounds 6a, 6c, 6l, 6m, and 7d possess 90-100% inhibition against most of the tested plants at the dosage of 1500 g ai/ha, whereas the title compounds 6b, 6g-h and 6n possess 92-100% inhibition against Fusarium oxysporum, Phyricularia grisea, Botrytis cinereapers, Gibberella zeae, Sclerotinia sclerotiorum, and Cercospora beticola at the concentration of 50mg/L.