442128-29-2

Upstream product

• 442127-97-1 2-(4-n-butylphenyl)-4,6-dichloropyrimidine 
• 1011806-24-8 2-(4-butyl-phenyl)-4,6-bis-(1-ethoxy-vinyl)-pyrimidine 

Downstream Products

• 1011806-39-5 C₁₂₄H₉₂N₂₂O₂ 
• 1011806-35-1 C₁₁₈H₉₆N₂₂ 
• 442128-59-8 4,6-bis(2-amino-3-formylpyridyl)-2-(4-n-butylphenyl)pyrimidine 

Relevant academic research and scientific papers

Naphthyridine-based helical foldamers and macrocycles: Synthesis, cation binding, and supramolecular assemblies

(Figure Presented) Unraveling the factors that control the conformation of molecular chains is of great interest both for understanding the shape of biological molecular strands and for designing artificial ones that adopt desired forms. Thus, a variety of artificial folding codons have been identified that enforce the formation, among others, of helices, strands, and loops, the major emphasis being on the shape of the foldamer. We report herein the synthesis and study of a family of foldamers and macrocycles based on the 1,8-naphthyridine and pyrimidine units, whose internal cavity is large enough to accommodate ionic substrates, and focus on the impact of guest binding within a cylindrical environment. Interestingly, the binding event within these large oligomers is translated to the outside of the receptors and affects the interaction of the overall complexes with the outside world. For instance, alkali cations bind to the one-turn helices and macrocycles to promote fibril formation and aggregation. Also, polyammonium substrates are able to tune the length of the overall helix assemblies and the rigidity of long oligomers. The reported data on one-turn, two-turn helices and macrocycles not only allows one to devise a model for the ion-controlled supramolecular assembly of such systems but also provides evidence that such controlled scaffolds bear promise in the design of complex systems.

Cation-promoted hierarchical formation of supramolecular assemblies of self-organized helical molecular components

Alternating naphthyridine-pyrimidine strands self-organize into a helical conformation containing a strongly polar cavity. The binding of metal and ammonium cations promotes supramolecular self-assembly in a sort of effector-induced growth process to form