442151-52-2Relevant academic research and scientific papers
Synthesis, biological evaluation, and in vivo imaging of the first camptothecin-fluorescein conjugate
Chevalier, Arnaud,Dubois, Martine,Le Joncour, Vadim,Dautrey, Sébastien,Lecointre, Céline,Romieu, Anthony,Renard, Pierre-Yves,Castel, Hélène,Sabot, Cyrille
, p. 1119 - 1133 (2013)
The first synthesis and photophysical properties of a fluorecently labeled camptothecin derivative, namely, camptothecin-FI (CPT-FI), an antitumoral agent that targets topoisomerase I, are reported. The preparation of this fluorescent conjugate is based o
New insights into the water-solubilisation of fluorophores by post-synthetic "click" and Sonogashira reactions
Massif, Cedrik,Dautrey, Sebastien,Haefele, Alexandre,Ziessel, Raymond,Renard, Pierre-Yves,Romieu, Anthony
supporting information; experimental part, p. 4330 - 4336 (2012/07/14)
New synthetic methodologies for the efficient chemical conversion of hydrophobic fluorescent dyes into bioconjugable and water-soluble derivatives are described. The combined use of an original sulfonated terminal alkyne and a metal-mediated reaction, namely the copper-catalysed Huisgen 1,3-dipolar cycloaddition ("click" reaction) or the Sonogashira cross-coupling, is the cornerstone of these novel post-synthetic sulfonation approaches.
