442155-91-1

Upstream product

• 13141-38-3 2-phenylethynylaniline 
• 98-59-9 p-toluenesulfonyl chloride 
• 536-74-3 phenylacetylene 
• 615-43-0 2-iodophenylamine 
• 61613-20-5 N-tosyl-2-iodoaniline 
• 452962-72-0 3-iodo-2-phenyl-1-(4-toluenesulfonyl)indole 
• 52670-38-9 2-ethynylaniline 
• 103529-16-4 2-[(trimethylsilyl)ethynyl]aniline 
• 6380-05-8 N-tosyl-2-chloroaniline 

Downstream Products

• 497236-40-5 N-ethynyl-4-methyl-N-(2-(phenylethynyl)phenyl)benzenesulfonamide 
• 1131260-21-3 C₂₄H₂₁NO₃S 
• 88207-51-6 2-phenyl-3-chloro-1-[(4-methylphenyl)sulfonyl]-1H-indole 
• 1236045-08-1 C₂₅H₂₃NO₅S 
• 1236044-88-4 C₂₈H₂₂N₂O₅S 
• 107734-06-5 N-tosyl-2-phenylindole 
• 1286189-69-2 (E)-2-(o-(N-tosylamino)phenyl)-3-phenylacrylic acid 
• 948-65-2 2-phenyl-indole 

Relevant academic research and scientific papers

Chiral indole compounds and preparation method thereof

The invention discloses chiral indole compounds and a preparation method thereof. Cyclobutanone compounds with iodine-substituted benzene ring ortho-positions and aryl sulfonamide compounds with acetenyl-substituted benzene ring ortho-positions are used a

Metal-free cascade boron–heteroatom addition and alkylation with diazo compounds

Transition metal-catalyzed carbene transfer reaction is one of the most notable advances for C?C bond formation reactionsduring the past decade, which has been widely employed in the preparation of C3-substituted indoles. Here, we described an efficient e

Catalytic Enantioselective Aminopalladation–Heck Cascade

Domino processes initiated by intramolecular nucleopalladation of alkynes have been developed into powerful synthetic tools for the synthesis of functionalized heterocycles. However, a catalytic enantioselective version of this class of reactions remains

Iridium-Catalyzed Isomerization/Cycloisomerization/Aromatization of N-Allyl-N-sulfonyl-o-(λ1-silylethynyl)aniline Derivatives to Give Substituted Indole Derivatives

We have developed a one-iridium-catalyst system that transforms N-allyl-N-sulfonyl-2-(silylalkynyl)aniline derivatives, which are 1,7-enynes in which both multiple bonds have a heteroatom, to the corresponding substituted indole derivatives via isomerizat

Diastereoselective [2+2+1] Hydrative Annulation of Phenol-Linked 1,6-Enynes with Acetylenes Through Rhodium Catalysis: A Rapid Access to Cyclopenta[b]benzofuranols

An unprecedented [2+2+1] hydrative annulation of 1,6-enynes with terminal alkynes is achieved using catalytic cationic Rh(I). Thus, a modular assembly of cyclopenta[b]benzofuranols with two consecutive quarternary stereocenters is achieved from readily available alkynes. The reaction is proposed to go through a sequence of 5-membered rhoda-cycle formation, regioselective acetylene insertion, 1,5 H-shift, substrate controlled stereoselective addition of water molecule followed by 1,2-rhodium migration gave contracted rhoda-cycle D and reductive elimination. Necessary control/labelling experiments were conducted to gain insight in to the mechanism.

Synthesis of 3-Methylthioindoles via Intramolecular Cyclization of 2-Alkynylanilines Mediated by DMSO/DMSO-d6 and SOCl2

The intramolecular cyclization of 2-alkynylanilines mediated by DMSO/SOCl2 was found to afford biologically interesting 3-methylthioindoles, which are rarely obtained by the exiting methods. DMSO could also be replaced with its deuterated count

Visible-Light-Mediated [2+2+1] Carbocyclization Reactions of 1,7-Enynes with Bromofluoroacetate to Form Fused Monofluorinated Cyclopenta[ c]quinolin-4-ones

Herein, we describe a new protocol for photoinduced radical [2+2+1] carbocyclization reactions of 1,7-enynes with bromofluoroacetate. These reactions, which proceed via a cascade involving fluoroalkylation, 6-exo-dig and 5-endo-trig cyclizations, H-transf

Strategies towards potent trypanocidal drugs: Application of Rh-catalyzed [2?+?2?+?2] cycloadditions, sulfonyl phthalide annulation and nitroalkene reactions for the synthesis of substituted quinones and their evaluation against Trypanosoma cruzi

Rhodium-catalyzed [2 + 2 + 2] cycloadditions, sulfonyl phthalide annulations and nitroalkene reactions have been employed for the synthesis of 56 quinone-based compounds. These were evaluated against Trypanosoma cruzi, the parasite that causes Chagas disease. The reactions described here are part of a program that aims to utilize modern, versatile and efficient synthetic methods for the one or two step preparation of trypanocidal compounds. We have identified 9 compounds with potent activity against the parasite; 3 of these were 30-fold more potent than benznidazole (Bz), a drug used for the treatment of Chagas disease. This article provides a comprehensive outline of reactions involving over 120 compounds aimed at the discovery of new quinone-based frameworks with activity against T. cruzi.

Synthesis of 2,3-disubstituted indoles from alkynylanilines and 2-chlorophenols using palladium–dihydroxyterphenylphosphine catalyst

2,3-Disubstituted indoles bearing 2-hydroxyphenyl moieties at their C3 positions were synthesized from readily available 2-chlorophenols and alkynylanilines via aminopalladation/reductive elimination using Pd–dihydroxyterphenylphosphine catalyst. The catalyst accelerates the introduction of the 2-hydroxyphenyl group at the C3 position of the indole.

A Commercially Available and User-Friendly Catalyst for Hydroamination Reactions under Technical Conditions

The activity of a simple, commercially available copper salt, [Cu(NCMe)4](BF4) in intramolecular hydroamination reactions of alkynes and allenes is presented. Reactions were successfully carried out in technical acetonitrile in the presence of air. While attempts of alkene hydroamination failed, this catalyst was also found active in intermolecular aza-Michael reactions.