442521-49-5

Basic information

• Product Name: acetic acid 1-acetoxymethyl-2-(4-bromo-2-nitro-phenyl)-ethyl ester
• Synonyms: acetic acid 1-acetoxymethyl-2-(4-bromo-2-nitro-phenyl)-ethyl ester
• CAS NO: 442521-49-5
• Molecular Weight: 360.161
• Mol File: 442521-49-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: acetic acid 1-acetoxymethyl-2-(4-bromo-2-nitro-phenyl)-ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: acetic acid 1-acetoxymethyl-2-(4-bromo-2-nitro-phenyl)-ethyl ester(442521-49-5)
• EPA Substance Registry System: acetic acid 1-acetoxymethyl-2-(4-bromo-2-nitro-phenyl)-ethyl ester(442521-49-5)

Safety Data

• Hazardous Substances Data: 442521-49-5(Hazardous Substances Data)

Upstream product

• 442521-40-6 ethyl 3-(4-bromo-2-nitrophenyl)-2-oxopropanoate 
• 60956-26-5 4-bromo-2-nitrotoluene 
• 108-24-7 acetic anhydride 
• 442521-41-7 3-(4-bromo-2-nitro-phenyl)-propane-1,2-diol 

Downstream Products

• 442521-58-6 2-({2-[3-(tert-butyl-dimethyl-silanyloxy)-2-hydroxy-propyl]-4,5-dipentyl-phenyl}-methyl-amino)-hexanoic acid benzyl ester 
• 442525-53-3 2-({2-[3-(tert-butyl-dimethyl-silanyloxy)-2-hydroxy-propyl]-5-octyl-phenyl}-methyl-amino)-hexanoic acid benzyl ester 
• 442521-65-5 (S)-2-{[2-(2,3-Dihydroxy-propyl)-5-octyl-phenyl]-methyl-amino}-hexanoic acid benzyl ester 
• 442521-54-2 acetic acid 1-acetoxymethyl-2-(2-formylamino-4-pentyl-5-pent-1-ynyl-phenyl)-ethyl ester 
• 442521-55-3 acetic acid 1-acetoxymethyl-2-(2-formylamino-4,5-dipentyl-phenyl)-ethyl ester 
• 442521-63-3 acetic acid 1-acetoxymethyl-2-(2-formylamino-4-octyl-phenyl)-ethyl ester 
• 442521-53-1 acetic acid 1-acetoxymethyl-2-(2-formylamino-5-iodo-4-pentyl-phenyl)-ethyl ester 
• 442521-56-4 3-(2-methylamino-4,5-dipentyl-phenyl)-propane-1,2-diol 
• 442521-52-0 acetic acid 1-acetoxymethyl-2-(2-amino-5-iodo-4-pentyl-phenyl)-ethyl ester 
• 442521-64-4 3-(2-methylamino-4-octyl-phenyl)-propane-1,2-diol 
• 442521-51-9 acetic acid 1-acetoxymethyl-2-(2-amino-4-pentyl-phenyl)-ethyl ester 
• 442521-62-2 acetic acid 1-acetoxymethyl-2-(2-nitro-4-oct-1-ynyl-phenyl)-ethyl ester 
• 442521-50-8 acetic acid 1-acetoxymethyl-2-(2-nitro-4-pent-1-ynyl-phenyl)-ethyl ester 

Relevant articles and documents

Synthesis, conformation and PKC isozyme surrogate binding of new lactone analogues of benzolactam-V8s

To investigate the role of the amide hydrogen of benzolactam-V8s (1-3) on protein kinase C (PKC) isozyme binding, new lactone analogues of benzolactam-V8s with hydrophobic side chains at positions 8 and/or 9 (5-8) were synthesized. The PKC binding affinities of 8- and 9-decylbenzolactone-V8 (5,6) were much lower than those of 8- and 9-decylbenzolactam-V8 (2,3), respectively, indicating that the amide hydrogen of benzolactam-V8s plays a critical role in PKC binding. 8-Decylbenzolactam-V8 (2) showed lower binding affinities to all PKC isozymes compared with those of 9-decylbenzolactam-V8 (3). The binding affinities of 8-substituted benzolactones (5,7,8) were also lower than those of 9-decylbenzolactone-V8 (6), but their PKC isozyme selectivity was higher than those of 2, 3 and 6. 8-Decybenzolactone-V8 (5) exhibited the most significant η-C1B selectivity among the four benzolactones (5-8) synthesized in this study.