442562-68-7Relevant academic research and scientific papers
4-aryl substituted indolinones
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, (2008/06/13)
The present invention relates to 4-arylindolinones, as well as pharmaceutical compositions thereof, capable of modulating protein kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation. The present invention also relates to methods for treating protein kinase related disorders.
Heteroatom- and carbon-linked biphenyl analogs of Brequinar as immunosuppressive agents
Batt, Douglas G.,Petraitis, Joseph J.,Sherk, Susan R.,Copeland, Robert A.,Dowling, Randine L.,Taylor, Tracy L.,Jones, Elizabeth A.,Magolda, Ronald L.,Jaffee, Bruce D.
, p. 1745 - 1750 (2007/10/03)
Structure-activity relationships were explored for some analogs of Brequinar having a linking atom between the 2-biphenyl substituent and the quinoline ring. Activities as inhibitors of dihydroorotate dehydrogenase and the mixed lymphocyte reaction were related to the overall shape and lipophilicity of the 2-substituent.
