442675-41-4Relevant academic research and scientific papers
A concise synthesis of β-asparaginyladenylate
Ding, Yun,Wang, Jianqiang,Schuster, Sheldon M.,Richards, Nigel G. J.
, p. 4372 - 4375 (2007/10/03)
Stable analogues of acyladenylate intermediates, such as N-acylphosphoramidates, are useful probes of tRNA aminoacylation and enzyme mechanism, and have potential application as enzyme inhibitors. We now report a concise, "one-pot" synthesis of β-asparaginyladenylate using a novel coupling protocol that yields the target N-acylphosphor-amidate in three reactions from readily available precursors. This simple synthetic procedure may represent a general approach for the preparation of functionalized N-acylphosphoramidates from amides that do not undergo coupling under the conditions of existing literature protocols.
