4427-85-4 Usage
Uses
Used in Pharmaceutical Industry:
(5beta)-3beta,14-dihydroxycardanolide is used as an active pharmaceutical ingredient for the development of cardiotonic drugs. Its ability to inhibit the sodium-potassium ATPase enzyme helps in the treatment of heart failure and atrial fibrillation by increasing the force of myocardial contractions and stabilizing heart rhythm.
Used in Chemical Synthesis:
(5beta)-3beta,14-dihydroxycardanolide is used as a key intermediate in the synthesis of various cardiac glycoside derivatives, such as aminoalkylthio digitalis derivatives. These derivatives are further evaluated for their receptor affinity and potential therapeutic applications in cardiovascular diseases.
Used in Drug Design and Development:
(5beta)-3beta,14-dihydroxycardanolide serves as a valuable template for the design and development of novel cardiotonic agents with improved pharmacological properties, reduced side effects, and enhanced efficacy. Its structural features and biological activity provide insights into the development of more selective and potent inhibitors of the sodium-potassium ATPase enzyme.
Used in Free-Wilson Analysis:
(5beta)-3beta,14-dihydroxycardanolide is utilized in a Free-Wilson analysis of 5β-14β-androstane derivatives that inhibit the sodium-potassium ATPase from human heart. This analysis helps in understanding the structure-activity relationship of these compounds and aids in the optimization of their therapeutic potential.
Check Digit Verification of cas no
The CAS Registry Mumber 4427-85-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,4,2 and 7 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 4427-85:
(6*4)+(5*4)+(4*2)+(3*7)+(2*8)+(1*5)=94
94 % 10 = 4
So 4427-85-4 is a valid CAS Registry Number.
4427-85-4Relevant academic research and scientific papers
Partial Syntheses of Cardenolides and Cardenolide Analogues. VI. (20R)- and (20S)-Cardanolides
Lindig, Claus,Repke, Kurt R. H.
, p. 574 - 586 (2007/10/02)
(20R)-Dihydrodigitoxigenin (2) and (20S)-dihydrodigitoxigenin (4) as well as their 3-acetates 3 and 5, respectively, were synthesized by catalytic hydrogenation of the appropriate cardenolides and separation by column chromatography on silica of the mixtures of stereoisomers.Hydroxymethylation of 3 and 5 followed by selective elimination yielded (20S)- and (20R)-14-hydroxy-22-methylene-5β,14β-cardanolide 3-acetate (10 and 16), respectively.The biological activities of the synthesized 20-stereoisomeric cardanolides are investigated and discussed.Cardanolides 10 and 16 have a strong inhibitory activity on the proliferation of Ehrlich ascites carcinoma cells in suspension culture.
