442850-71-7

Basic information

• Product Name: 1-tert-Butyl-1H-pyrazol-5-aMine
• Synonyms: 1-tert-Butyl-1H-pyrazol-5-aMine;5-AMino-1-tert-butylpyrazole;1H-Pyrazol-5-aMine, 1-(1,1-diMethylethyl)-
• CAS NO: 442850-71-7
• Molecular Formula: C₇H₁₃N₃
• Molecular Weight: 139.19822
• Mol File: 442850-71-7.mol

Chemical Properties

• Boiling Point: 247.5±13.0℃ (760 Torr)
• Flash Point: 103.5±19.8℃
• Appearance: /
• Density: 1.05±0.1 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 1-tert-Butyl-1H-pyrazol-5-aMine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-tert-Butyl-1H-pyrazol-5-aMine(442850-71-7)
• EPA Substance Registry System: 1-tert-Butyl-1H-pyrazol-5-aMine(442850-71-7)

Safety Data

• Hazardous Substances Data: 442850-71-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research and Development:
1-tert-butyl-1H-pyrazol-5-amine is used as a building block for the synthesis of various drugs and biologically active compounds, contributing to the development of new therapeutic agents.
Used in Organic Synthesis:
1-tert-butyl-1H-pyrazol-5-amine is utilized as a key intermediate in the synthesis of complex organic molecules, facilitating the creation of a wide range of chemical products.
Used in Coordination Chemistry:
1-tert-butyl-1H-pyrazol-5-amine is used as a ligand in the coordination chemistry of transition metals, playing a crucial role in the formation of metal complexes with specific properties and applications.
Used in Material Science:
1-tert-butyl-1H-pyrazol-5-amine has potential applications in the development of new materials with tailored properties and functions, such as in catalysis, sensors, or other advanced material technologies.

Upstream product

• 7400-27-3 tertbutylhydrazine hydrochloride 
• 920-37-6 2-Chloroacrylonitrile 

Downstream Products

• 1010086-61-9 N-(1-tert-butyl-1H-pyrazol-5-yl)-6-chloropyrazin-2-amine 
• 442850-79-5 N-(2-tert-butyl-2H-pyrazol-3-yl)-thiobenzamide 
• 442850-73-9 N-(2-tert-butyl-2H-pyrazol-3-yl)-benzamide 

Relevant articles and documents

5- OR 7-AZAINDAZOLES AS BETA-LACTAMASE INHIBITORS

The present invention relates to β-lactamase inhibitors having the following general formula (I): wherein R1-R4 and X1-X2 are defined in the specification, pharmaceutical composition thereof, and use thereof for the treatment of a bacterial infection, alone or in combination with β-lactam antibiotics and/or other antibiotics and/or other β-lactamase inhibitors.

Gas-phase synthesis of pyrazolo[3,4- b ]pyridin-4-ones

Flash vacuum pyrolysis (FVP) at 500-600 °C of 1-substituted pyrazolylaminomethylene derivatives of Meldrum's acid provides 1-substituted pyrazolo[3,4-b]pyridin-4-ones in high yields. If the 1-substituent is a tert-butyl group, FVP at 750-850 °C causes elimination of 2-methyl-1-propene to give the parent pyrazolo[3,4-b]pyridin-4-one.

Syntheses of 1-substituted-3-aminopyrazoles

A series of 1-substituted-3-aminopyrazoles were prepared via Chan-Lam coupling reactions, alkylation, and pyrazole ring formation.

Novel aminopyridine derivatives having aurora a selective inhibitory action

The present invention relates to a compound of formula I: wherein: R1 is a hydrogen atom, F, CN, etc.; R1′ is a hydrogen atom or lower alkyl which may be substituted; R2 is O, S, SO, SO2, etc.; R3 is