4429-97-4Relevant academic research and scientific papers
Direct access to pyrimidines through organocatalytic inverse-electron-demand Diels-Alder reaction of ketones with 1,3,5-triazine
Yang, Gongming,Jia, Qianfa,Chen, Lei,Du, Zhiyun,Wang, Jian
, p. 76759 - 76763 (2015/09/28)
An organocatalytic inverse-electron-demand Diels-Alder reaction of ketones with 1,3,5-triazine through enamine catalysis has been developed. This method could furnish 4,5-disubstituted pyrimidines in good yields and high levels of regioselectivities.
One-step synthesis of 4,5-disubstituted pyrimidines using commercially available and inexpensive reagents
Baran, Phil S.,Shenvi, Ryan A.,Nguyen, Steven A.
, p. 581 - 586 (2008/02/02)
4,5-Disubstituted pyrimidines are synthesized from the corresponding ketone in one-step using inexpensive reagents (formamidine acetate, n-propanol, heat). Contrasted to other methods, this process appears quite amenable to large-scale use in industrial settings.
