442910-62-5

Basic information

• Product Name: tert-Butyl 7-methyl-1H-indole-1-carboxylate
• Synonyms: 1H-Indole-1-carboxylic acid, 7-Methyl-, 1,1-diMethylethyl ester;1-BOC-7-methylindole;tert-Butyl 7-methyl-1H-indole-1-carboxylate;7-Methyl-1H-indole, N-BOC protected
• CAS NO: 442910-62-5
• Molecular Formula: C₁₄H₁₇NO₂
• Molecular Weight: 231.29
• Product Categories: blocks;IndolesOxindoles
• Mol File: 442910-62-5.mol

Chemical Properties

• Boiling Point: 337.278°C at 760 mmHg
• Flash Point: 157.78°C
• Appearance: /
• Density: 1.064g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.537
• Storage Temp.: 2-8°C
• CAS DataBase Reference: tert-Butyl 7-methyl-1H-indole-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl 7-methyl-1H-indole-1-carboxylate(442910-62-5)
• EPA Substance Registry System: tert-Butyl 7-methyl-1H-indole-1-carboxylate(442910-62-5)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 442910-62-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Tert-Butyl 7-methyl-1H-indole-1-carboxylate is used as a building block in organic synthesis for the preparation of various pharmaceuticals. Its unique chemical structure allows it to be a key component in the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, tert-Butyl 7-methyl-1H-indole-1-carboxylate is utilized as a precursor in the synthesis of various agrochemicals. Its chemical properties make it suitable for the development of compounds with pesticidal or herbicidal properties, contributing to crop protection and yield enhancement.
Used in Fine Chemicals Industry:
Tert-Butyl 7-methyl-1H-indole-1-carboxylate is also employed in the synthesis of fine chemicals, which are high-purity chemicals used in various applications such as fragrances, dyes, and specialty chemicals. Its versatility and stability make it a valuable component in the production of these high-quality products.

InChI:InChI=1/C14H17NO2/c1-10-6-5-7-11-8-9-15(12(10)11)13(16)17-14(2,3)4/h5-9H,1-4H3

Upstream product

• 85507-12-6 buta-2,3-dien-1-yl methanesulfonate 
• 79641-99-9 tert-butyl (3-methylfuran-2-yl)carbamate 
• 933-67-5 7-methyl-1H-indole 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 442910-45-4 tert-butyl 7-(bromomethyl)-1H-indole-1-carboxylate 
• 1256360-03-8 tert-butyl 7-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylate 
• 914349-39-6 tert-butyl 3-bromo-7-methylindole-1-carboxylate 

Relevant articles and documents

INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS

Provided herein are compounds of formula (V) that bind to BF3 of an androgen receptor (AR), which can modulate the AR for the treatment of Kennedy's disease.

An entry to 2-(cyclobut-1-en-1-yl)-1: H -indoles through a cyclobutenylation/deprotection cascade

A transition-metal-free strategy for the synthesis of 2-(cyclobut-1-en-1-yl)-1H-indoles under mild conditions is described herein. A series of substituted 2-(cyclobut-1-en-1-yl)-1H-indoles are accessed by a one-pot cyclobutenylation/deprotection cascade from N-Boc protected indoles. Preliminary experimental and density functional theory calculations suggest that a Boc-group transfer is involved in the underlying mechanism.

Formation of 6-Azaindoles by Intramolecular Diels-Alder Reaction of Oxazoles and Total Synthesis of Marinoquinoline A

A new variant of the intramolecular Diels-Alder oxazole (IMDAO) cycloaddition that provides direct access to 6-azaindoles was developed. The IMDAO reaction was applied in a total synthesis of the aminophenylpyrrole-derived alkaloid marinoquinoline A, also

TRANSGLUTAMINASE 2 (TG2) INHIBITORS

Described herein are compounds and pharmaceutical compositions containing such compounds which inhibit transglutaminase 2 (TG2). Also described herein are methods for using such TG2 inhibitors, alone or in combination with other compounds, for treating diseases or conditions that would benefit from TG2 inhibition.

Substituted Indoles

The invention provides for compounds of formula (I) wherein R1, R2, R3, R4, R5, and R6 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, th

SUBSTITUTED 7-SULFANYLMETHYL-, 7-SULFINYLMETHYL- AND 7-SULFONYLMETHYLINDOLES AND THE USE THEREOF

The present application relates to novel 7-sulfanylmethyl-, 7-sulfinylmethyl- and 7-sulfonylmethylindole derivatives, processes for the preparation thereof, the use thereof alone or in combinations for the treatment and/or prevention of diseases, and the use thereof for the manufacture of medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of cardiovascular disorders.

Efficient N-tert-butoxycarbonylation of indoles with di-tert-butyl dicarbonate catalyzed by cesium fluoride

An environmentally friendly process for the tert-butoxycarbonylation of indoles with di-tert-butyl dicarbonate has been developed. Catalytic amount of cesium fluoride can accelerate this tert-butoxycarbonylation. Georg Thieme Verlag Stuttgart.

Synthesis of N-protected/free indole-7-carboxaldehyde

A direct method for the preparation of N-protected/free indole-7-carboxaldehyde is reported from the corresponding N-protected 7-bromomethylindoles using three different conditions. Copyright Taylor & Francis Group, LLC.