443122-22-3Relevant academic research and scientific papers
Identification and synthesis of N-(thiophen-2-yl) benzamide derivatives as BRAFV600E inhibitors
Xie, Yunfeng,Chen, Xianjie,Qin, Jie,Kong, Xiangqian,Ye, Fei,Jiang, Yuren,Liu, Hong,Jiang, Hualiang,Marmorstein, Ronen,Luo, Cheng
, p. 2306 - 2312 (2013/04/24)
The V600E BRAF kinase mutation, which activates the downstream MAPK signaling pathway, commonly occurs in about 8% of all human malignancies and about 50% of all melanomas. In this study, we employed virtual screening and chemical synthesis to identify a
