443147-36-2

Upstream product

• 82542-42-5 Methyl (Z)-7-<(3R)-3-<(tert-Butyldimethylsilyl)oxy>-5-oxo-1-cyclopentenyl>-5-heptenoate 
• 443147-32-8 3-(S)-t-butyldimethylsilyloxy-1-iodo-4-(4-t-butyldimethylsilyloxy-3-methylphenyl)-1-butene 
• 148344-51-8 4-bromo-2-methyl-1-(2'-tetrahydropyranyloxy)benzene 
• 443147-28-2 3-(S)-hydroxy-4-(4-hydroxy-3-methylphenyl)-1-butyne 
• 443147-24-8 2-(S)-tetrahydropyranyloxy-3-(4-tetrahydropyranyloxy-3-methylphenyl)propan-1-al 
• 443147-26-0 3-(S)-tetrahydropyranyloxy-4-(4-tetrahydropyranyloxy-3-methylphenyl)-1-butyne 
• 443147-22-6 2-(S)-tetrahydropyranyloxy-3-(4-tetrahydropyranyloxy-3-methylphenyl)propan-1-ol 
• 443147-20-4 1-acetoxy-3-(4-tetrahydropyranyloxy-3-methylphenyl)-2-(S)-tetrahydropyranyloxypropane 
• 443147-34-0 1,1-dibromo-3-(S)-tetrahydropyranyloxy-4-(4-tetrahydropyranyloxy-3-methylphenyl)-1-butene 
• 443147-14-6 2-(S)-hydroxy-3-(4-tetrahydropyranyloxy-3-methylphenyl)propan-1-ol trityl ether 

Downstream Products

• 443147-48-6 (Z)-7-{(1R,2R,3R,5R)-5-Chloro-3-hydroxy-2-[(E)-(S)-3-hydroxy-4-(4-hydroxy-3-methyl-phenyl)-but-1-enyl]-cyclopentyl}-hept-5-enoic acid methyl ester 
• 443147-47-5 (Z)-7-((1R,2R,3R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-{(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-4-[4-(tert-butyl-dimethyl-silanyloxy)-3-methyl-phenyl]-but-1-enyl}-5-hydroxy-cyclopentyl)-hept-5-enoic acid methyl ester 
• 443147-38-4 (Z)-7-{(1R,2R,3R)-3-Hydroxy-2-[(E)-(S)-3-hydroxy-4-(4-hydroxy-3-methyl-phenyl)-but-1-enyl]-5-oxo-cyclopentyl}-hept-5-enoic acid methyl ester 

Relevant academic research and scientific papers

Design and synthesis of a selective EP4-receptor agonist. Part 3: 16-phenyl-5-thiaPGE(1) and 9-beta-halo derivatives with improved stability.

To identify a new selective EP4-agonist with improved chemical stability, further chemical modification of those reported previously was continued. We focused our attention on chemical modification of the alpha chain of 3,7-dithiaPGE(1) and selected 5-thi