4432-44-4

Usage

Uses

Used in Polymer and Resin Production:
2-(Morpholinomethyl)acrylic acid is used as a monomer in the production of various polymers and resins. Its unique chemical structure allows it to form strong covalent bonds with other monomers, resulting in the creation of durable and versatile materials with a wide range of applications.
Used as a Cross-linking Agent:
In the synthesis of hydrogels and other materials, 2-(Morpholinomethyl)acrylic acid is used as a cross-linking agent. Its ability to form covalent bonds with other molecules enables the formation of a three-dimensional network structure, which is essential for the stability and functionality of hydrogels and other materials.
Used in Pharmaceutical and Biological Reagent Manufacturing:
2-(Morpholinomethyl)acrylic acid is also used as a component in the manufacturing of pharmaceuticals and biological reagents. Its unique chemical properties make it a valuable building block for the development of new drugs and diagnostic tools.
It is important to handle 2-(Morpholinomethyl)acrylic acid with proper care, as it can cause irritation to the skin, eyes, and respiratory system upon contact or inhalation. Additionally, it may have harmful effects on aquatic organisms and the environment if not properly managed.

Upstream product

• 110-91-8 morpholine 
• 50-00-0 formaldehyd 
• 141-82-2 malonic acid 

Downstream Products

• 1453199-55-7 2-(5-chloro-2-(2-methoxy-5-(2-(morpholinomethyl)acrylamido)phenylamino)pyrimidin-4-ylamino)-Nmethylbenzamide 

Relevant academic research and scientific papers

NEW COMPOUND HAVING FGFR INHIBITORY ACTIVITY AND PREPARATION AND APPLICATION THEREOF

The present invention relates to a new compound having an FGFR inhibitory activity and preparation and application thereof. In particular, the compound according to the present invention has a structure as shown in formula I, wherein each group and substituent are as defined in the description. Also disclosed in the present invention are a preparation method for the compound and a use thereof in preparation of a drug for treating and/or preventing a tumor-related disease and/or an FGFR-related disease.

SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS TYROSINE KINASE INHIBITORS

This invention provides compounds of formula (1) wherein X is C3-7 cycloalkyl, pyridinyl, pyrimidinyl or phenyl ring optionally substituted as described in claim 1, R1, R3 and R4 are chosen from the groups listed in claim 1. R2 is chosen from various unsaturated acyl groups listed in claim 1, with certain compounds being disclaimed. Use as tyrosine kinase inhibitors for the treatment of cancer and certain kidney diseases such as polycystic kidney disease.

Substituted quinazoline derivatives

This invention provides compounds of formula 1 having the structure wherein: X, R1, R2, R3, R4, Z, X, and n are as defined hereinbefore in the specification, which are useful as antineoplastic agents and in the treatment of certain kidney diseases, such as polycystic kidney disease.

The Mannich reaction of malonic acid. A efficient route to some α-functionalized acrylates

Various α-functionalized acrylates can be easily synthesized by means of the Mannich reaction of malonic acid with paraformaldehyde and secondary aliphatic amines.