443304-99-2Relevant articles and documents
Efficient total synthesis of khafrefungin: Convergent approach using Suzuki coupling under thallium-free conditions toward multigram-scale synthesis
Mori, Yuichiro,Nakamura, Masayuki,Wakabayashi, Takeshi,Mori, Kouhei,Kobayashi, Shu
, p. 601 - 603 (2002)
An efficient and practical synthetic route to khafrefungin, an antifungal agent, has been developed based on successive coupling of three components, 3, 4, and then 2. A key step of the synthesis is the Suzuki coupling of 2 and 10, in which the use of tox