443305-29-1

Basic information

• Product Name: 1-CHLORO-5,7-DIMETHYL-3,4-DIHYDRO-NAPHTHALENE-2-CARBALDEHYDE
• Synonyms: 1-CHLORO-5,7-DIMETHYL-3,4-DIHYDRO-NAPHTHALENE-2-CARBALDEHYDE
• CAS NO: 443305-29-1
• Molecular Formula: C₁₃H₁₃ClO
• Molecular Weight: 220.69
• Mol File: 443305-29-1.mol

Chemical Properties

• Boiling Point: 338.9±42.0 °C(Predicted)
• Appearance: /
• Density: 1.18±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 1-CHLORO-5,7-DIMETHYL-3,4-DIHYDRO-NAPHTHALENE-2-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-CHLORO-5,7-DIMETHYL-3,4-DIHYDRO-NAPHTHALENE-2-CARBALDEHYDE(443305-29-1)
• EPA Substance Registry System: 1-CHLORO-5,7-DIMETHYL-3,4-DIHYDRO-NAPHTHALENE-2-CARBALDEHYDE(443305-29-1)

Safety Data

• Hazardous Substances Data: 443305-29-1(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
1-CHLORO-5,7-DIMETHYL-3,4-DIHYDRO-NAPHTHALENE-2-CARBALDEHYDE is used as a building block in organic synthesis for the preparation of various chemical compounds due to its versatile intermediate properties.
Used in Medicinal Chemistry:
1-CHLORO-5,7-DIMETHYL-3,4-DIHYDRO-NAPHTHALENE-2-CARBALDEHYDE is used as a key intermediate in the development of pharmaceuticals, contributing to the synthesis of potential drug candidates.
Used in Fine Chemicals Production:
1-CHLORO-5,7-DIMETHYL-3,4-DIHYDRO-NAPHTHALENE-2-CARBALDEHYDE is used as a starting material in the production of fine chemicals, which are essential in various industries such as cosmetics, fragrances, and flavors.
Used in Pharmaceutical Industry:
1-CHLORO-5,7-DIMETHYL-3,4-DIHYDRO-NAPHTHALENE-2-CARBALDEHYDE is used as a precursor in the synthesis of pharmaceuticals, playing a crucial role in the development of new drugs.
Used in Agrochemicals Production:
1-CHLORO-5,7-DIMETHYL-3,4-DIHYDRO-NAPHTHALENE-2-CARBALDEHYDE is used as a component in the production of agrochemicals, which are vital for agricultural applications such as pest control and crop protection.
Used in Academic Research and Drug Discovery:
1-CHLORO-5,7-DIMETHYL-3,4-DIHYDRO-NAPHTHALENE-2-CARBALDEHYDE is used as an important target in academic research and drug discovery efforts, owing to its unique structure and properties.

Upstream product

• 13621-25-5 5,7-dimethyltetralone 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 443305-27-9 1-(2-methoxy-phenyl)-5,7-dimethyl-3,4-dihydro-naphthalene-2-carbaldehyde 
• 443305-24-6 1-(2-methoxy-phenyl)-5,7-dimethyl-3,4-dihydro-naphthalene-2-carboxylic acid 

Relevant articles and documents

Synthesis and biological evaluation of guanylhydrazone coactivator binding inhibitors for the estrogen receptor

Most patients with hormone-responsive breast cancer eventually develop resistance to traditional antiestrogens such as tamoxifen, and this has become a major obstacle in their treatment. We prepared and characterized the activity of a series of 16 guanylhydrazone small molecules that are designed to block estrogen receptor (ER) activity through a non-traditional mechanism, by directly interfering with coactivator binding to agonist-liganded ER. The inhibitory activity of these compounds was determined in cell-based transcription assays using ER-responsive reporter gene and mammalian two-hybrid assays. Several of the compounds gave IC50 values in the low micromolar range. Two secondary assays were used to confirm that these compounds were acting through the proposed non-traditional mode of estrogen inhibitory action and not as conventional antagonists at the ligand binding site.

4,5-DIHYDRONAPHTHO [1,2-b] THIOPHENE DERIVATIVE

A 4,5-dihydronaphtho[1,2-b]thiophene derivative expressed by the formula: (wherein R1 is a C1 to C10 1-hydroxyalkyl group or a C1 to C10 acyl group, and R2 and R3 separately substitute in the 6-, 7-, 8-, or 9-positions, and are each independently a hydrogen atom, a halogen atom, a C1 to C10 alkyl group, a hydroxy group, a C1 to C10 alkoxy group, a C1 to C5 alkenyloxy group, a C1 to C5 alkynyloxy group, a benzyloxy group, or the like, provided that when R1 is an acyl group and R2 is a hydrogen atom, then R3 is neither a hydrogen atom nor an acetyl group), or a pharmaceutically acceptable salt thereof. This is a novel compound that is effective in reducing triglyceride levels in the liver and reducing blood glucose levels.

A rapid access to coumarin derivatives (using Vilsmeier-Haack and Suzuki cross-coupling reactions)

A four-step preparation of compounds containing a coumarinic moiety is presented. This synthesis involves notably a Suzuki cross-coupling reaction (performed in aqueous media) and a ring closure by formation of δ-lactone.