HPD-OSu is a heterobifunctional crosslinker chemical that is widely utilized for the conjugation of proteins or peptides to carrier proteins and antibodies. It features both amine-reactive N-hydroxysuccinimide (NHS) ester and maleimide groups, which enable it to be employed in a variety of bioconjugation and crosslinking applications. The NHS ester group of HPD-OSu is reactive with primary amines of proteins, while the maleimide group is reactive with sulfhydryl groups of cysteine residues in proteins or peptides. This dual reactivity allows for the selective and efficient conjugation of multiple biomolecules, making HPD-OSu a valuable tool for studying protein-protein interactions, creating antibody-drug conjugates, and developing targeted drug delivery systems.
443305-33-7
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Basic information
- Product Name: HPD-OSu
- Synonyms: 2-(2,5-dioxopyrrolidin-1-yloxy)-1,3-dimethyl-3,4,5,6-tetrahydropyrimidin-1-ium hexafluorophosphate(V);PyriMidiniuM,2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-1,4,5,6-tetrahydro-1,3-diMethyl-,hexafluorophosphate(1-)
- CAS NO:443305-33-7
- Molecular Formula: C10H16N3O3.PF6
- Molecular Weight: 371.22
- EINECS: N/A
- Product Categories: N/A
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Chemical Properties
- Melting Point: 170-172 °C
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: HPD-OSu(CAS DataBase Reference)
- NIST Chemistry Reference: HPD-OSu(443305-33-7)
- EPA Substance Registry System: HPD-OSu(443305-33-7)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 443305-33-7(Hazardous Substances Data)
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443305-33-7 Usage
Uses
Used in Pharmaceutical Industry:HPD-OSu is used as a bioconjugation agent for the development of antibody-drug conjugates. It facilitates the attachment of therapeutic agents to antibodies, enhancing the targeting of drugs to specific cells or tissues, thereby improving the efficacy and reducing the side effects of treatments.
Used in Research and Development:
HPD-OSu is used as a crosslinking agent for studying protein-protein interactions. It allows researchers to covalently link proteins or peptides to each other, providing insights into the structure, function, and dynamics of protein complexes.
Used in Drug Delivery Systems:
HPD-OSu is used as a key component in the design and synthesis of targeted drug delivery systems. It enables the conjugation of drugs to carrier proteins or nanoparticles, improving the delivery, bioavailability, and therapeutic outcomes of various pharmaceuticals.
Check Digit Verification of cas no
The CAS Registry Mumber 443305-33-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,4,3,3,0 and 5 respectively; the second part has 2 digits, 3 and 3 respectively.Calculate Digit Verification of CAS Registry Number 443305-33:
(8*4)+(7*4)+(6*3)+(5*3)+(4*0)+(3*5)+(2*3)+(1*3)=117
117 % 10 = 7
So 443305-33-7 is a valid CAS Registry Number.
443305-33-7 Well-known Company Product Price
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Alfa Aesar
(H26418) O-Succinimidyl-1,3-dimethylpropyleneuronium hexafluorophosphate, 98%
443305-33-7
1g
726.0CNY
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Alfa Aesar
(H26418) O-Succinimidyl-1,3-dimethylpropyleneuronium hexafluorophosphate, 98%
443305-33-7
5g
2215.0CNY
- Detail
443305-33-7Upstream product
443305-33-7Downstream Products
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HPD-OSu
