443306-99-8Relevant academic research and scientific papers
A convenient procedure for the preparation of α-aminoallenes using a three-component reaction of aldehyde, carbamate and propargylsilane
Billet, Manuella,Schoenfelder, Angèle,Klotz, Philippe,Mann, André
, p. 1453 - 1456 (2002)
A three-component reaction is described using an aldehyde, a carbamate and trimethylpropargylsilane in the presence of a Lewis acid for the production in moderate to good yield of α-allenyl amines. The reaction is applicable to aromatic or aliphatic aldehydes. The obtained α-aminoallenes are transformed into Δ3-pyrrolidines or amino acids by using the reactivity of the cumulene function.
