443326-13-4

Upstream product

• 2033-24-1 cycl-isopropylidene malonate 
• 14268-66-7 benzo[1,3]dioxolo-5-ylamine 
• 135-02-4 ortho-anisaldehyde 
• 84465-82-7 tetrahydro-3,4,5,6-dimethyl-6,6-pyrannedione-2,4 

Downstream Products

• 1429518-82-0 5-(2-methoxyphenyl)-4,5-dihydro-[1,3]dioxolo[4,5-g][1,2,4]triazolo[1,5-a]quinoline 

Relevant academic research and scientific papers

Inhibitors of late SV40 factor (LSF) as cancer chemotherapeutics

The present invention is directed to methods, compositions and kits for treatment of cancer, e.g. heptacellular carcinoma. In some embodiments, the present invention discloses the use of a small-molecule compound of formulas (I)-(XXVI) as disclosed herein to inhibit transcription factor Late SV40 Factor (LSF) for treatment of cancer, e.g., HCC.

ZrOCl2 · 8H2O: An efficient, ecofriendly, and recyclable catalyst for ultrasound-accelerated, one-pot, solvent-free synthesis of 8-aryl-7,8-dihydro-[1,3]dioxolo[4,5-g] quinolin-6-(5H)-one and 4-aryl-3,4-dihydroquinolin-2(1 H)-one derivatives

A convenient, one-pot, solvent-free reaction of amines, aromatic aldehydes, and Meldrum's acid to form 8-aryl-7,8-dihydro-[1,3]dioxolo[4,5-g]quinolin-6- (5H)-one and 4-aryl-3,4-dihydroquinolin-2-(1H)-one in the presence of 10 mol% ZrOCl2 · 8H2O under ultrasonic irradiation is described. This new protocol offers several advantages including low catalyst loading, clean reaction, easy workup, use of recyclable and ecofriendly catalyst, short reaction times, good yields, and solvent-free conditions. Copyright

[1,3]DIOXOLO[4,5-G]QUINOLINE-6(5H)THIONE AND [1,3]DIOXOLO[4,5-G][1,2,4]TRIAZOLO[1,5-A]QUINOLINE DERIVATIVES AS INHIBITORS OF THE LATE SV40 FACTOR (LSF) FOR USE IN TREATING CANCER

The present invention relates generally to [l,3]dioxolo[4,5-g]quinoline-6(5H)thione and [1,3]dioxolo[4,5-g][1,2,4]triazolo[1,5-a]quinoline derivatives and/or compositions for use in inhibiting, preventing and/or treating cancer, e.g. hepatocellular carcionoma (HCC). In some embodiments, the invention relates to the use of small-molecule compounds to inhibit, prevent and/or treat expression of the transcription factor Late SV40 Factor (LSF) for treatment of HCC or other cancer types.

Ultrasound-promoted one-pot synthesis of 8-aryl-7,8-dihydro-[1,3]- dioxolo[4,5-g]quinolin-6(5H)-one derivatives under catalyst-free and solvent-free conditions

An ultrasound-accelerated one-pot procedure has been explored for the synthesis of 8-aryl-7,8-dihydro-[1,3]-dioxolo[4,5-g]quinolin-6(5H)-one derivatives using the reaction between 3,4-methylendioxyaniline 1, aldehyde 2 and isopropylidene malonate 3 under catalyst-free and solvent-free conditions. High yields of the products, mild reaction condition, environmentally friendly procedure, catalyst- and solvent-free conditions are the main advantages of this protocol.