4435-33-0Relevant academic research and scientific papers
A TEMPO-like nitroxide combined with an alkyl-substituted pyridine: An efficient catalytic system for the selective oxidation of alcohols with iodine
Kashparova, Vera P.,Klushin, Victor A.,Zhukova, Irina Yu.,Kashparov, Igor S.,Chernysheva, Daria V.,Il'chibaeva, Irina B.,Smirnova, Nina V.,Kagan, Efim Sh.,Chernyshev, Victor M.
supporting information, p. 3517 - 3521 (2017/10/05)
An efficient method for the oxidation of alcohols to aldehydes or ketones in a two-phase CH2Cl2/NaHCO3 (aq.) system, using iodine and catalytic amounts of 4-acetylamino-2,2,6,6-tetramethylpiperidine-1-oxyl and 2,4,6-trimethylpyridine, was developed. The performance of the method was demonstrated by the selective oxidation of 37 variously substituted alcohols in ≥90% yield, including the gram-scale synthesis of the important chemical 2,5-diformylfuran from biomass-derived 5-hydroxylmethylfurfural.
Counterion effects in the preparation of aldehyde-bisulfite adducts
Kissane, Marie G.,Frank, Scott A.,Rener, Gregory A.,Ley, Christopher P.,Alt, Charles A.,Stroud, Paul A.,Vaid, Radhe K.,Boini, Sathish K.,McKee, Laura A.,Vicenzi, Jeffrey T.,Stephenson, Gregory A.
supporting information, p. 6587 - 6591 (2013/11/19)
The identification and development of an aldehyde-bisulfite adduct as an isolable starting material in the synthesis of the CETP inhibitor Evacetrapib are described. The physical properties of the sodium and potassium analogs are compared, and the extension of the scope of this study to include an investigation into the solid state properties of a range of sodium and potassium bisulfite adducts of commonly encountered aldehydes is discussed.
Metabolites of the Higher Fungi. Part 19. Serpenone, 3-Methoxy-4-methyl-5-prop-1-enylfuran-2(5H)-one, a new γ-Butyrolactone from the Fungus Hypoxylon serpens (Barrons strain) (Persoon ex Fries)Kickx
Anderson, John R.,Edwards, Raymond L.,Whalley, Anthony J. S.
, p. 215 - 222 (2007/10/02)
Culture solutions of the fungus Hypoxylon serpens (Barrons strain) contain a new butyrolactone as the major metabolite, which has been identified as 3-methoxy-4-methyl-5-prop-1-enylfuran-2(5H)-one (2),and small quantities of the reduced analogue, 3-methoxy-4-methyl-5-propylfuran-2(5H)-one (3); the structures have been established by synthesis of compound (3).A new rapid synthesis of the isomeric 4-methoxy-3,5-disubstituted analogues is described and the two groups of compounds are compared spectroscopically.
