443682-81-3

Basic information

• Product Name: 5,5-dimethyl-3-(2-phenylethyl)-1,4,2-dioxazole
• Synonyms: 5,5-dimethyl-3-(2-phenylethyl)-1,4,2-dioxazole
• CAS NO: 443682-81-3
• Molecular Weight: 205.257
• Mol File: 443682-81-3.mol

Chemical Properties

• CAS DataBase Reference: 5,5-dimethyl-3-(2-phenylethyl)-1,4,2-dioxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5,5-dimethyl-3-(2-phenylethyl)-1,4,2-dioxazole(443682-81-3)
• EPA Substance Registry System: 5,5-dimethyl-3-(2-phenylethyl)-1,4,2-dioxazole(443682-81-3)

Safety Data

• Hazardous Substances Data: 443682-81-3(Hazardous Substances Data)

Upstream product

• 17698-11-2 N-hydroxy-3-phenylpropanamide 
• 126-84-1 2,2-diethoxypropane 

Downstream Products

• 22767-95-9 1-methylethyl 3-phenylpropionoate 
• 17698-11-2 N-hydroxy-3-phenylpropanamide 
• 443682-82-4 5,5-dimethyl-3-(1-methyl-2-phenylethyl)-1,4,2-dioxazole 
• 70079-43-5 2-methyl-3-phenylpropionohydroxamic acid 
• 2021-28-5 ethyl dihydrocinnamate 
• 34666-01-8 ethyl 2-methyl-3-phenylpropionate 
• 102-93-2 3-phenylpropionamide 

Relevant articles and documents

5,5-Dimethyl-1,4,2-dioxazoles as versatile aprotic hydroxamic acid protecting groups

5,5-Dimethyl-1,4,2-dioxazoles are readily installed by transketalization of 2,2-diethoxypropane, where both the NH and OH moieties are protected in a nonprotic form. The dioxazoles are stable to a wide variety of reaction conditions and readily revert back to the hydroxamic acid by treatment with Nafion-H in 2-propanol. The method is applicable to primary, secondary, tertiary, and aromatic hydroxamic acids, and the acidity of the protons adjacent to the dioxazole allows α-functionalization.