443751-31-3Relevant academic research and scientific papers
Synthesis and enzymatic characterization of P1-thio-P2-oxo trideoxynucleoside diphosphates having AZT, FdU, or dT at the 3'-position
Oetvoes, Laszlo,Bajor, Zoltan,Kraicsovits, Ferenc,Sagi, Gyula,Tegyey, Zsuzsanna
, p. 79 - 92 (2007/10/03)
Model compounds for oligonucleotide-prodrugs, P1-thio-P2-oxo-tri-deoxyribonucleoside diphosphates: d[G5C0X] and d[TsA0X] (X = AZT, FdU or dT) have been prepared, and their hydrolyses by snake venom phosphodiesterase and nuclease S1 are described.
