443893-70-7Relevant academic research and scientific papers
1,2,3-Triazole-containing uracil derivatives with excellent pharmacokinetics as a novel class of potent human deoxyuridine triphosphatase inhibitors
Miyakoshi, Hitoshi,Miyahara, Seiji,Yokogawa, Tatsushi,Endoh, Kanji,Muto, Toshiharu,Yano, Wakako,Wakasa, Takeshi,Ueno, Hiroyuki,Chong, Khoon Tee,Taguchi, Junko,Nomura, Makoto,Takao, Yayoi,Fujioka, Akio,Hashimoto, Akihiro,Itou, Kenjirou,Yamamura, Keisuke,Shuto, Satoshi,Nagasawa, Hideko,Fukuoka, Masayoshi
supporting information; experimental part, p. 6427 - 6437 (2012/09/22)
Deoxyuridine triphosphatase (dUTPase) has emerged as a potential target for drug development as a 5-fluorouracil-based combination chemotherapy. We describe the design and synthesis of a novel class of human dUTPase inhibitors, 1,2,3-triazole-containing u
Synthesis and thermal properties for 4-(4-alkoxyphenoxycarbonyl)phenyl 3-alkoxy-2-X-benzoates
Okamoto, Hiroaki,Morita, Yuki,Segawa, Yoichi,Takenaka, Shunsuke
, p. 221/[2087]-227/[2093] (2007/10/03)
Some derivatives of 4-(4-alkoxyphenoxycarbonyl)phenyl 3-alkoxy-2-X- benzoates (X=F, Cl, Br, or CF3) were synthesized by means of an ortho-directed lithiation followed by an electrophilic aromatic substitution reaction, as a key step, and their
