4439-83-2

Usage

Uses

Used in Pharmaceutical Applications:
Norvaline, 4-oxo(9CI) is used as a pharmaceutical agent for its antioxidative and neuroprotective properties, which may contribute to the prevention and treatment of various diseases and conditions associated with oxidative stress and neurodegeneration.
Used in Food Additive Industry:
In the food additive industry, Norvaline, 4-oxo(9CI) is utilized for its potential to enhance the quality and shelf life of food products, thanks to its antioxidative properties that can help prevent spoilage and maintain freshness.
Used in Biochemical Research:
Norvaline, 4-oxo(9CI) serves as a valuable compound in biochemical research, where it is used to study the function and regulation of enzymes involved in protein synthesis, providing insights into the molecular mechanisms underlying various biological processes.
Used in Bodybuilding and Athletic Supplements:
In the sports nutrition industry, Norvaline, 4-oxo(9CI) is used as a supplement ingredient to potentially enhance muscle growth and performance, making it an attractive option for athletes and bodybuilders seeking to improve their physical capabilities.

InChI:InChI=1/C5H9NO3/c1-3(7)2-4(6)5(8)9/h4H,2,6H2,1H3,(H,8,9)/p-1

Upstream product

• 82518-90-9 diethyl 2-acetamido-2-acetonylmalonate 
• 100056-15-3 N-Formyl-α-aethoxycarbonyl-γ-oxo-DL-norvalin-aethylester 
• 58486-97-8 2-Benzamido-4-oxopentansaeure,N-Benzoyl-β-acetylalanin 
• 18635-62-6 Ketophalloidin 
• 215716-71-5 2-Amino-4-fluoro-pent-4-enoic acid tert-butyl ester 
• 207459-88-9 (R)-2-(2,2,5,7,8-Pentamethyl-chroman-6-sulfonylamino)-5-trimethylsilanyl-pent-4-ynoic acid 
• 159141-18-1 (2R)-N-(2,2,5,7,8-Pentamethylchroman-6-ylsulfonyl)-2-((1R)-[1-2H₁]-3-trimethylsilylprop-2-ynyl)glycine 
• 207459-89-0 (S)-2-(2,2,5,7,8-Pentamethyl-chroman-6-sulfonylamino)-5-trimethylsilanyl-pent-4-ynoic acid 
• 215716-69-1 tert-butyl 2-(benzhydrylideneamino)-4-fluoropent-4-enoate 

Downstream Products

• 67809-70-5 N-Benzyloxycarbonyl-β-acetylalanin 
• 4439-84-3 L-δ-Hydroxy-γ-oxo-norvalin 
• 123102-57-8 4-oxo-2-(N'-phenyl-ureido)-valeric acid 

Relevant academic research and scientific papers

Synthesis of the suicide substrate D-propargylglycine stereospecifically labelled with deuterium and investigation of its oxidation by D-amino acid oxidase

Stereospecifically deuteriated samples of D-propargylglycine 1 have been prepared by reaction of the labelled Pmc-protected aziridine free acids 22 with a lithium acetylide followed by deprotection. These samples have been used to show that D-amino acid oxidase, in converting D-propargylglycine to the lactone 5, deprotonates C-3 in a non-stereospecific manner. This strongly supports the idea that non-enzymic deprotonation is a key step in the formation of this compound.

3-Bromo-2-fluoropropene - a fluorinated building block. 2-fluoroallylation of glycine and alanine ester imines

3-Bromo-2-fluoropropene (4) is prepared in a new three-step synthesis from ammonium α-fluoroacrylate (1) in 31% overall yield. Glycine and alanine ester imines are efficiently alkylated by 4 to give, after deprotection, 2-amino-4-fluoropent-4enoic acid (9) in 63% overall yield, and the α-methylated derivalive 13 in 26% overall yield, respectively. Preliminary results indicate that 4 is potentially a new a-carbonyl cation equivalent.

Components of the Green Deathcap Toadstool Amanita phalloides, LVIII. - Some Dithiolanes Derived from Ketophalloidin as Reagents in Biochemical Research

Ketophalloidin (2), obtained from phalloidin (1) by oxidation with periodate, was transformed into the dithiolanecarboxylic acid 3 by reaction with 2,3-dimercaptopropionic acid, and into the (aminomethyl)dithiolane 4 by reaction with 3-amino-1,2-propanedithiol.Compound 4 was the starting material for the following derivatives: the N-(3-carboxypropionyl) compound 5, the N-iodoacetyl compound 6 and, by nucleophilic substitution of iodide by azide, for the azidoacetyl compound 8.A fluorescent phallotoxin (7) was obtained by reaction of 4 with fluorescein isothiocyanate.All phallotoxins described in this paper specifically bind, like phalloidin, to the receptor protein actin.Derivatives 6 and 7, as radioactively labeled molecules, are suitable for a covalent fixation to actin (affinity labeling); the functional derivatives 3,4 and 5 have been conjugated to bovine serum albumin, and the amino compound 4 has been covalently attached to activated sepharose in order to generate an adsorbent for affinity chromatography