443988-47-4

Basic information

• Product Name: Acetic acid, diazo(triethylsilyl)-, phenylmethyl ester
• CAS NO: 443988-47-4
• Molecular Formula: C15H22N2O2Si
• Molecular Weight: 290.437
• Mol File: 443988-47-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Acetic acid, diazo(triethylsilyl)-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid, diazo(triethylsilyl)-, phenylmethyl ester(443988-47-4)
• EPA Substance Registry System: Acetic acid, diazo(triethylsilyl)-, phenylmethyl ester(443988-47-4)

Safety Data

• Hazardous Substances Data: 443988-47-4(Hazardous Substances Data)

Upstream product

• 79271-56-0 triethylsilyl trifluoromethyl sulfonate 
• 52267-51-3 benzyl diazoacetate 

Downstream Products

• 443988-54-3 benzyl 2-triethylsilyl-2-oxoacetate 

Relevant articles and documents

Synthesis and use of α-silyl-substituted α-hydroxyacetic acids

(matrix presented) Rhodium-catalyzed oxygen transfer was used to generate benzyl 2-silyl-2-oxoacetates in good yields. The hydrogenation of these compounds led to chiral α-silyl-substituted α-hydroxyacetic acids. Resolution by means of HPLC using a chiral stationary phase afforded an enantiomerically pure representative of this class of compounds, which was successfully applied as a chiral ligand in an asymmetric aldol-type reaction.