443998-73-0

Basic information

• Product Name: 4'-AMINOBIPHENYL-3-CARBONITRILE
• Synonyms: SALOR-INT L300683-1EA;4'-AMINOBIPHENYL-3-CARBONITRILE;4'-AMINO[1,1'-BIPHENYL]-3-CARBONITRILE;AKOS BAR-0462;3-(4-AMINOPHENYL)BENZONITRILE;4μ-Amino-[1,1μ-biphenyl]-3-carbonitrile, 4μ-Aminobiphenyl-3-carbonitrile;4’-Amino-3-cyanobiphenyl
• CAS NO: 443998-73-0
• Molecular Formula: C₁₃H₁₀N₂
• Molecular Weight: 194.23
• Mol File: 443998-73-0.mol
• Article Data: 4

Chemical Properties

• Melting Point: 128-132 °C(lit.)
• Boiling Point: 375.1 °C at 760 mmHg
• Flash Point: 180.7 °C
• Appearance: /
• Density: 1.18 g/cm³
• CAS DataBase Reference: 4'-AMINOBIPHENYL-3-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-AMINOBIPHENYL-3-CARBONITRILE(443998-73-0)
• EPA Substance Registry System: 4'-AMINOBIPHENYL-3-CARBONITRILE(443998-73-0)

Safety Data

• Hazard Codes: Xi,N,Xn
• Statements: 41-50-20/21/22
• Safety Statements: 26-39-61-60-36/39
• RIDADR: UN 3077 9 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 443998-73-0(Hazardous Substances Data)

Usage

General Description

4’-Aminobiphenyl-3-carbonitrile, also known as 4-Amino-3-cyano-biphenyl, is an organic compound with the chemical formula C13H10N2. It is a derivative of biphenyl with an amino group and a nitrile group attached to the central carbon atom. 4'-Aminobiphenyl-3-carbonitrile is widely used in organic synthesis and pharmaceutical research as a building block for the production of various pharmaceuticals and other organic compounds. It is also utilized in the production of dyes, pigments, and other chemicals. Additionally, it has been studied for its potential biological activities, including its potential use as an anticancer agent. However, it is important to handle 4’-Aminobiphenyl-3-carbonitrile with caution, as it may be hazardous if not properly handled or disposed of.

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Relevant articles and documents

3-Hydroxypyrimidine-2,4-diones as Selective Active Site Inhibitors of HIV Reverse Transcriptase-Associated RNase H: Design, Synthesis, and Biochemical Evaluations

Human immunodeficiency virus (HIV) reverse transcriptase (RT) associated ribonuclease H (RNase H) remains an unvalidated antiviral target. A major challenge of specifically targeting HIV RNase H arises from the general lack of selectivity over RT polymerase (pol) and integrase (IN) strand transfer (ST) inhibitions. We report herein the synthesis and biochemical evaluations of three novel 3-hydroxypyrimidine-2,4-dione (HPD) subtypes carefully designed to achieve selective RNase H inhibition. Biochemical studies showed the two subtypes with an N-1 methyl group (9 and 10) inhibited RNase H in low micromolar range without siginificantly inhibiting RT polymerase, whereas the N-1 unsubstituted subtype 11 inhibited RNase H in submicromolar range and RT polymerase in low micromolar range. Subtype 11 also exhibited substantially reduced inhibition in the HIV-1 INST assay and no significant cytotoxicity in the cell viability assay, suggesting that it may be amenable to further structure-activity relationship (SAR) for identifying RNase H inhibitors with antiviral activity.

Biaryl ureas as potent and orally efficacious melanin concentrating hormone receptor 1 antagonists for the treatment of obesity

Herein, we report a small molecule MCH-R1 antagonist which demonstrates oral efficacy in chronic rodent models. Substituted phenyl biaryl urea derivatives were synthesized and evaluated as MCH-R1 antagonists for the treatment of obesity. The structure-activity relationship studies in this series resulted in identification of urea 1 as a potent and selective MCH-R1 antagonist. Compound 1 exhibited oral efficacy in chronic (28 d) rodent models at 3-30 mpk showing significant reduction in food intake and weight gain relative to controls.