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• 2698-41-1 o-chlorobenzylidene malononitrile 
• 109-77-3 malononitrile 

Relevant academic research and scientific papers

Efficient one-pot synthesis of pyrano[2,3-d]pyrimidinone and pyrido [2,3-d] pyrimidine derivatives by using of Mn-ZIF-8?ZnTiO3 nanocatalyst

Mn-ZIF-8?ZnTiO3 nanocomposite was synthesized by sol-gel method. The morphology and structure of the nanocrystalline Mn-ZIF-8?ZnTiO3 was characterized by SEM, TEM, BET, XRD. The results confirmed the formation of Mn-ZIF-8?ZnTiO3 nanocomposite with particl

Aqueous hydrotropic solution: green reaction medium for synthesis of pyridopyrimidine carbonitrile and spiro-oxindole dihydroquinazolinone derivatives

Abstract: From the green chemistry point of view, water is one of the most sustainable solvents for chemical transformations, but there are some limitations to its use as a reaction medium due to the lack of solubility of organic compounds. To overcome this difficulty, we used aqueous hydrotropic solution, which increases the solubility of organic compounds in water by?200-fold. We report an environmentally efficient method for synthesis of pyridopyrimidine carbonitriles and spiro-oxindole dihydroquinazolinones by using 50?% aqueous sodium p-toluene sulfonate (NaPTS) solution at ambient reaction condition. The merits of the present protocol include short reaction time, excellent product yield?with high purity, easy workup procedure and reusability of reaction medium. Graphical abstract: [Figure not available: see fulltext.].

DABCO-based ionic liquids: Introduction of two metal-free catalysts for one-pot synthesis of 1,2,4-triazolo[4,3-a] pyrimidines and pyrido[2,3-d] pyrimidines

Straightforward methods for the synthesis of 1,2,4-triazolo[4,3-a]pyrimidine and pyrido[2,3-d]pyrimidine derivatives are described through three-component condensation of aromatic aldehydes, malononitrile, and 3-amino-1,2,4-triazole or 6-amino-1,3-dimethyluracil. In both procedures two affordable and metal-free DABCO-based ionic liquids are employed as catalysts and the obtained outcomes are compared with each other. All reactions are performed under mild conditions during acceptable reaction times in good to high yields. After ensuring the efficiency of the catalysts in both reactions, four new derivatives are synthesized and their structures are characterized by FT-IR, 1H NMR and 13C NMR. Simplicity, easy work-up procedures and recoverability of the catalysts are other advantages of these methods.

Efficient synthesis of pyrano[2,3-d]pyrimidinone and pyrido[2,3-d]pyrimidine derivatives in presence of novel basic ionic liquid catalyst

A basic ionic liquid, namely 1,1′-(butane-1,4-diyl)bis(1,4-diazabicyclo [2.2.2]octan-1-ium) hydroxide, was prepared and characterized using Fourier-transform infrared spectroscopy, 1H nuclear magnetic resonance spectroscopy, and pH measurements. The ionic liquid was used for efficient promotion of the synthesis of pyrano[2,3-d]pyrimidinone and pyrido[2,3-d]pyrimidine derivatives at room temperature under grinding conditions. A simple procedure, short reaction time, high yields, non-column chromatographic separation, commercial availability of the starting materials, and recyclability of the catalyst are attractive features of this process.

Structure-based design of pyridopyrimidinediones as dipeptidyl peptidase IV inhibitors

Dipeptidyl peptidase IV (DPP-4) inhibitors have been shown to enhance GLP-1 levels and thereby improve hyperglycemia in type II diabetes. From a small fragment hit, using structure-based design, we have discovered a new class of non-covalent, potent and s