444083-23-2

Upstream product

• 932-87-6 1-Bromo-2-phenylacetylene 
• 331258-83-4 (+)-(2R,3R)-3-phenoxy-1-(2-propenyl)-4-oxoazetidine-2-carbaldehyde 
• 277757-76-3 (+)-(3R,4S)-1-(2-propenyl)-4-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]-3-methoxy-2-azetidinone 
• 1794-48-5 1-bromo-3-phenylprop-2-yne 

Relevant academic research and scientific papers

New aspects of the indium chemistry of carbonyl-β-lactams

Reactions of racemic as well as optically pure carbonyl-β-lactams with stabilized organo-indium reagents were investigated in aqueous media. The regio- and stereochemistry of the processes were generally good, offering a convenient asymmetric entry to den

Synthesis of strained tricyclic β-lactams by intramolecular [2+2] cycloaddition reactions of 2-azetidinone-tethered enallenols: Control of regioselectivity by selective alkene substitution

A convenient metal-free methodology for the preparation of structurally novel, strained tricyclic β-lactams containing a cyclobutane ring has been developed. The first examples accounting for the intramolecular [2+2] cycloaddition reactions in β-lactams h

New regiocontrolled synthesis of functionalized pyrroles from 2-azetidinone-tethered allenols

A new one-pot approach to synthesize densely substituted racemic and enantiopure pyrroles from β-lactams has been developed. The approach relies on the regiocontrolled cyclization of β-allenamine intermediates derived from the ring opening of 2-azetidinon

Domino metal-free allene-β-lactam-based access to functionalized pyrroles

A novel transition metal-free domino reaction sequence in allene-β-lactams, leading to the biologically relevant pyrrole frame has been developed using a sodium methoxide-methanol system. The Royal Society of Chemistry 2006.

Structurally Novel Bi- and Tricyclic β-Lactams via [2 + 2] Cycloaddition or Radical Reactions in 2-Azetidinone-Tethered Enallenes and Allenynes

(Matrix presented) Thermolysis of β-lactam-tethered enallenyl alcohols gave tricyclic ring structures via a formal [2 + 2] cycloaddition of the alkene with the distal bond of the allene, while the tin-promoted radical cyclization in 2-azetidinone-tethered

Additions of allenyl/propargyl organometallic reagents to 4-oxoazetidine-2-carbaldehydes: Novel palladium-catalyzed domino reactions in allenynes

Metal-mediated carbonyl allenylation and propargylation of 4-oxoazetidine-2-carbaldehydes were investigated in aqueous environment. Different propargyl bromide and metal promoters showed varied regio- and stereoselectivities on product formation. In addit